Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Amelioration Of Curcumin Of Nicotine Induced Necrosis Of Different Tissues Of Female Rats In Protein Restricted Condition | 6043
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 3732

Journal of Analytical & Bioanalytical Techniques received 3732 citations as per Google Scholar report

Journal of Analytical & Bioanalytical Techniques peer review process verified at publons
Indexed In
  • CAS Source Index (CASSI)
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Academic Journals Database
  • Open J Gate
  • Genamics JournalSeek
  • JournalTOCs
  • ResearchBible
  • China National Knowledge Infrastructure (CNKI)
  • Ulrich's Periodicals Directory
  • Electronic Journals Library
  • RefSeek
  • Directory of Research Journal Indexing (DRJI)
  • Hamdard University
  • OCLC- WorldCat
  • Scholarsteer
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Euro Pub
Share This Page

Amelioration of Curcumin of Nicotine Induced Necrosis of Different Tissues of Female Rats in Protein Restricted Condition

International Conference & Exihibition On Analytical and Bioanalytical Techniques - 2010

Brajadulal Chattopadhyay, Satyam Banerjee and Krishna Chattopadhyay

ScientificTracks Abstracts: J Anal Bioanal Techniques

DOI: 10.4172/2155-9872.1000001

Uses of different forms of nicotine (smoking and smokeless tobacco products) have been a major public health issue for many years. It is related with several cancers, cardiovascular disorder and many other diseases. Low dietary protein possesses a constraint on the metabolic activity and results in impaired detoxification machinery. The adverse effects of nicotine on different organs under protein restricted condition are still unclear. This study was performed to investigate the ameliorative effect of curcumin against nicotine induced changes in different tissues under protein restricted condition. Albino-rats were maintained under normal/ protein-restricted diets and subcutaneously injected with nicotine tartrate (2.5 mg/ kg body weight/day) and orally supplemented with curcumin (80 mg/kg body weight/ day) for 21 days. The effects of the drugs were monitored by comet assay, UV- visible and CD-spectroscopy, and molecular docking. Cytokine profile and gene expression studies were performed by ELISA and Real-time-PCR respectively. Nicotine binds to DNA and distorts its structure at low concentrations and induces strand breaks at high concentration (>1mM). Curcumin revives nicotine induced structural changes of DNA. Nicotine elevates IL-6, TNF-α and STAT3 expression more in protein restricted condition and enhances p65 and Bcl-2 expression more in normal condition. Over-expression of antiapoptotic protein and DNA structural alteration by nicotine in normal diet condition indicates higher chances of malignant transformation of cells, whereas extensive DNA damage and inflammatory responses in protein restricted diet indicates cell-necrosis. Curcumin effectively ameliorates nicotine induced changes in both dietary conditions.