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An Overview Of Synthetic Prostaglandins, Steroids And Their Bioanalytical Challenges | 6078
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

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An Overview of Synthetic Prostaglandins, Steroids and their Bioanalytical Challenges

International Conference & Exihibition On Analytical and Bioanalytical Techniques - 2010

D. Vijaya Bharathi

ScientificTracks Abstracts: J Anal Bioanal Techniques

DOI: 10.4172/2155-9872.1000001

Abstract
Synthetic Prostaglandins are analogs or derivatives of prostaglandins that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGE. Synthetic prostaglandins are used to induce childbirth (parturition) or abortion, to prevent closure of patent ductus arterious in new borns with particular cyanotic heart defects, to prevent and treat peptic ulcers, as a vasodilator in ischemia, in pulmonary hypertension, in treatment of glucoma, to treat erctile dysfunction and used as an ingredient in eyelash and eyebrow growth beauty products. Synthetic prostaglandins namely misoprostol, enprostil, rioprostil, arabaprostil, metenoprost, lubiprostone etc. A steroid is a type of organic compound that contains a specific arrangement of four rings that are joined to each other. Examples of steroids include cholesterol, the sex hormones estradiol and testosterone, and the anti-inflammatory drug dexamethasone. Biequivalence studies play an important role is establishing invivo equivalence and most of the synthetic prostaglandins and steroids bioanalytical method development is challenging due to low dose formulation demand of sensitive methods and stability issues. In detail discussion on factors meeting consideration of MS/MS measurements of steroids and prostaglandins are presented, chromatographic conditions, instrumentation information like HPLC, LCMS detection parameters, sample preparations, recovery details, limit of detection and limit of quantification, Tmax, Cmax etc, for application in BA/BE studies of pharmaceuticals was incorporated in the current presentation. 4 case studies 2 from each category are depicted.
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