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Human health is most important for any country. Throughout the world spending
percentage for keeping the good health of people is huge. Drug (medicine)
discovery as well as its development is complex and highly competitive processes
that are defined as the series of specialized events performed to satisfy quality criteria.
In the development of the drugs (medicines), several steps are taken to assess their
effectiveness on the particular disease with minimal side effects due to the main
drug and no harmful effects due to the impurities present in the drug. It becomes
very obvious to analyze the purity of the drug and impurities present in the drug. To
understand these aspects, analysis of drugs in bulk and in formulations becomes
essential. To analyze the drugs in formulations, one should have a proper method
in which the drug is properly separated, identified and quantified. Time to time new
methods need to be developed and validated to analyse these drug species in the
bulk and formulation. To this end, High Performance Liquid Chromatography (HPLC)
is the most important analytical technique in the pharmaceutical industry to test the
products for both qualitative and quantitative analysis. HPLC methods are relatively
standard and used to test the raw material, bulk drugs and formulations. Here we
describe a simple, sensitive, reproducible and rapid HPLC methods developed and
validated for some selected drugs: Ritonavir, Atomoxetine, Repaglinide, Valacyclovir
and Glimipiride in pharmaceutical formulations.
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