Antidiabetic And Antihyperlipidaemic Effect Of Hydro-alcoholic Extract Of Calencula Officinalis | 6058
Journal of Analytical & Bioanalytical Techniques
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Calendula officinalis, belonging to the family of Asteraceae, commonly known as
English Marigold or Pot Marigold is an aromatic herb which is used in Traditional
System of Medicine. It is mainly used because of its various biological activities to
treat diseases like analgesic, antidiabetic and anti-inflammatory. It is also used for
ingastro-intestinal, gynecological, eye disease, skin injuries and in some cases of
burn. The plant is rich in many pharmaceutical active ingredients like Carotenoids,
flavonoids, glycosides, steroids and sterols. Thus the present study was designed
to evaluate the antidiabetic and antihyperlipidemic effect of hydroalcoholic extract
of calendula officinalis (CRHAt) in alloxan induced diabetic rats. The extract was
prepared by soxhlet extraction technique with a ratio of Water : Alcohol (70:30)
for 36 hrs which ensured complete extraction of active constituents.Diabetes was
induced by single intraperitoneal injection of alloxan (150 mg/kg) of body weight.
Oral administration of alcoholic CRHAt to diabetic rats, at a dose of 100 mg/kg body
weight, resulted in a significant reduction in blood glucose, urine sugar and serum
lipids in alloxan diabetic rats. The extract also increases the total haemoglobin lever.
The extract effect was similar to that of insulin. Thus, the investigation clearly shows
that alcoholic CRHAt has both antidiabetic and antihyperlipidaemic effects.
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