Journal of Analytical & Bioanalytical Techniques
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Major progress in cancer chemotherapy requires new drugs to eradicate the entire neoplastic diseases in human being. Finding
of novel structure leads that may be of use in designing new, potent, selective, and less toxic anticancer agents remains a
major challenge for medicinal chemistry researchers. Random screening of natural products and synthetics has been the source
of new leads in approaches to drug discovery. In our ongoing search for the new potential ant tumor agents, we therefore aimed
to develop a series of heterocyclic compounds with pharmaceutical interest. Many planar heteroaromatic derivatives have shown
anti-proliferative activity in vitro and some of them are important anticancer drugs. Some of these types of compounds have the
thiophene, thiazole, pyridine and hydrazide-hydrazones nucleus which represent structural component of a large number of
biologically active natural and unnatural compounds. Such finding encourage us to synthesis a series of heterocyclic compounds
incorporated thiophene, thiazole, pyrazole nucleous together with the anti-tumor evaluation of the newly synthetic products.
Rafat Mohareb has completed his Ph. D at the age of 26 years from Cairo University. He got full Professor in 1994, participating with International
fellows foundations like: the Alexander von Humboldt foundation, Full bright and the Arab-fund Foundation for Social and economic developments.
He was published around 125 papers in the field of Pharmaceutical Chemistry.
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