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Aspects Of Recent Developments Of Smart Multi-way Calibration Methods Coupled With LC-MS And LCDAD In Analytical Chemistry | 95968
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

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Aspects of recent developments of smart multi-way calibration methods coupled with LC-MS and LCDAD in analytical chemistry

World Congress on Mass Spectrometry and Analytical Techniques

Hai Long Wu

Hunan University, China

Keynote: J Anal Bioanal Tech

DOI: 10.4172/2155-9872-C2-029

Multi-way calibration methods having second-order or extended advantages are gaining more and more attentions in the field of analytical sciences. It is a smart and green quantitative analysis strategy based on mathematical separation for complicated chemical systems when combined with advanced analytical instruments capable of generating multidimensional arrays, e.g. HPLC-DAD, LC-MS and EEMs. It enables one to quantify directly and rapidly the component(s) of analytical interest even in the presence of unknown interferences not included in the calibration samples and makes the final goal of analytical chemistry achievable even without the aid of complicated separation procedures. These multi-way calibration methods could be applied to resolve different problems of qualitative and quantitative analysis in complicated chemical systems by combining with the advanced analytical instruments. The performances of these algorithms have been evaluated by using simulated and real experimental datasets. They have been utilized to simultaneous or direct determinations of multiple component(s) of analytical interest in many fields such as pharmaceutical, biomedical, environmental, food sciences. The main points on successful applications of these chemometric methods combined with advanced analytical instruments have been also summarized. Some recent developments on the theories and their applications of multi-way calibration methodologies including second- and thirdorder calibration are also reviewed in detail.

Hai Long Wu is a Professor of Analytical Chemistry of the College of Chemistry and Chemical Engineering at Hunan University since 1999 and the Former Director of the State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University. He has completed his BS in 1982 and MSc in 1985 as well as Doctor of Science in 1992 in Analytical Chemistry from Hunan University. He has worked at Hunan University during and then went to Japan and received his Doctor of Engineering in Applied Chemistry from Chiba University, Japan in 1998. He has published over 230 papers in LC-DAD, LC-MS, chemometrics and chemical sensors in international journals.

E-mail: [email protected]