Comparative Study Of Formulations Of Ondansetron Hydrochloride Orodispersible Tablets By Effervescent And Sublimation Methods | 18771
Journal of Analytical & Bioanalytical Techniques
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Oral drug delivery has been known for decades as the most widely utilized route of administration. Dysphagia is a common
problem encountered in all age groups in concern to solid dosage forms. To solve the problem of dysphagia and to
improve patient compliance orodispersible tablets emerged as an alternative to conventional oral dosage forms. Ondansetron
hydrochloride is a selective 5-HT3 receptor antagonist which acts as antiemetic. In the present work orodispersible tablets of
ondansetron hydrochloride were formulated by effervescent and sublimation method using factorial design. In the effervescent
method, crospovidone (1.31%-4.68%) was used as superdisintegrant whereas citric acid (7.95%-18.04%) and sodium
bicarbonate (5.22%-28.77%) were used as effervescent agent. In the sublimation method, crospovidone (1.58%-4.41%) was
used as superdisintegrant whereas camphor (6.34%-17.35%) was used as subliming agent. The prepared batches of tablets were
evaluated for hardness, friability, drug content uniformity, wetting time, disintegration time and
drug release pattern.
Total 15 batches were formulated by effervescent method and 9 batches were formulated by sublimation method. Disintegration
time of the formulations prepared by effervescent method was found between 13-36 secs whereas formulations prepared by
sublimation method showed disintegration time between 7-39 secs. Among all the formulations, the formulation (S6) prepared
by sublimation method using crospovidone 4% and camphor 8% was found to have the minimum disintegration time (7
seconds). Finally, it was concluded that orodispersible tablet of ondansetron hydrochloride can be successfully formulated
using effervescent and sublimation method and can be used as a novel drug dosage form for pediatric and geriatric with
improved patient compliance and enhanced bioavailability.
Shrawani lamichhane has completed her graduation from Tribhuwan University, Nepal in 2014.
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