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Tobacco is a greater cause of death and disability than any other single disease.
India is the 3rd largest tobacco producing country after USA and China. Use
of different forms of tobacco is increasing day by day. Nicotine, the acute acting
pharmacological agents of tobacco, plays the major role for drug of addiction.
Elucidation of the complex effect of nicotine has worldwide implications. Nutritional
status alters the actions, potencies and detoxification of toxicants. Any strategy
through natural diet that prevents or slows the progression and severity of nicotine
toxicity has a significant health impact. Nicotine induces oxidative stress. In search
for natural antioxidants, present study was undertaken to evaluate the antioxidant
efficacy of sesame lignans and conjugated linolenic acid, in nicotine treated rats.
Experiments were conducted on male albino rats (120 � 130 g body weight) by
injecting nicotine tartrate (3.5 mg/kg body wt. /day for 15 days) subcutaneously and
thereby supplementing sesame lignans (0.2 g/100 g diet) and conjugated linolenic
acid (0.2 g/100 g diet) orally to them simultaneously. Results showed that serum
and liver lipid profile, activities of antioxidant enzymes, lipid peroxidation altered
significantly due to oxidative stress generated by nicotine. Supplementation of
sesame lignans and conjugated linolenic acid attenuates all the altered parameters
by their antioxidant property. Results also showed that antioxidant activity of
conjugated linolenic acid was more prominent than that of sesame lignans.
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