Comparison Of Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Products On Human Low-density And High-density Lipoproteins By ESI-MS Analyses | 18728
Journal of Analytical & Bioanalytical Techniques
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Oxidized products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC) are pro-inflammatory and
bioactive.The amounts and structures of oxidized PAPC products on lipoproteinshave not been fully understoodyet. In
this study, lipoproteins were oxidized by Fenton reaction. Phospholipids on lipoproteins were then isolated by liquid-liquid and
solid-phase extractions.ESI-MS analysiswas used to analyze oxidized PAPC products on human low-density lipoprotein (LDL)
and high-density lipoprotein (HDL).A total of 9 long-chain and 10 short-chain oxidized PAPC products have beenanalyzed.
The ion intensities of six oxidized PAPC products including m/z = 820.5, 836.5, 850.5, 622, 650 and 690 are significantly higher
for oxidized LDL than for native LDL. However, the ion intensities of oxidized PAPC productsisolated fromoxidized HDL and
native HDL are similar.
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