Development And Application Of Electrochemical Biosensor For The Clinical Diagnosis Of Preeclampsia | 18755
Journal of Analytical & Bioanalytical Techniques
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Preeclampsia is a pregnancy associated hypertensive disorder that arises during the second half of pregnancy with probable
risk for survival of mother or baby or both. It is characterized by hypertension, proteinuria (urinary excretion of 300 mg/
greater of protein in 24 h time period), with potential danger to liver, kidneys, brain and the clotting system. Studies carried out
at different stages of preeclampsia suggested an increase in the expression of anti-angiogenic (soluble Fms-like tyrosine kinase,
soluble endoglin etc.) and oxidative stress molecules as well as hyperglycosylated human chorionic gonadotrophin (hCG-H)
with a decrease in the expression of angiogenic molecules, proteases, placental proteins etc. in the maternal blood circulation.
An early detection of the change in expression of these molecules would assist in effective management of this condition; as
prognosis is good if, diagnosed early. Development of a highly sensitive and specific diagnostic method would be instrumental
in achieving this important goal. Although, preeclampsia sensor has not been developed so far, however, some related
biomarkers of preeclampsia such as; vascular endothelial growth factor, soluble endoglin, and molecules for the oxidative stress
have been attempted in recent years. Data will be presented on the development of nanomaterial-bioreceptor conjugates based
electrochemical biosensor for the highly sensitive and on site analysis of the biomolecules related to preeclampsia.
Pankaj Suman did Bachelors? degree in Veterinary Sciences from Maharashtra Animal and Fishery Sciences University, Nagpur, Masters? degree in Biotechnology
from Indian Institute of Technology Roorkee India and Doctoral and post-doctoral studies at the National Institute of Immunology, New Delhi India. Currently, he
is working as Assistant Professor at the Amity University, Noida where his major research interests are to discover novel biomarker and to develop ultrasensitive
multiplex biosensor for the early detection of preeclampsia in pregnant woman. He has published about 20 papers in reputed journals and received several awards
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