A new, simple and sensitive spectrophotometric method for the determination of tenofovir has been developed. The method is
based on the condensation of tenofovir with 1, 2- napthaquinone-4- sulfonic acid sodium (NQS) in alkaline media to yield
orange colored product. Tenofovir showed maximum absorbance at 334 nm with linearity was observed in the concentration
range of 2-12 μg/ml (R
= 0.990). The relative standard deviation of 0.531% and recovery of tenofovir in tablet showed 99.33?0.52.
The proposed method is simple, rapid, precise and convenient for the assay of tenofovir in pharmaceutical formulation.
Geeta Bhavani Balija is a student of JSS College of Pharmacy, JSS University, Mysore. She has completed her B.Pharm from H.L.T College of
Pharmacy, Banglore. Presently she is pursuing her M.Pharm Degree in the branch of Pharmaceutical analysis. Her current area of research is on
analytical method development of novel drugs.
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