Journal of Analytical & Bioanalytical Techniques
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
The present manuscript describes simple, sensitive, rapid, accurate, precise, reproducible and economical Q-absorbance ratio
method for the simultaneous determination of Cinitapride Hydrogen Tartrate (CINI) and Rabeprazole Sodium (RABE) in
combined tablet dosage form. Q-absorbance ratio method uses the ratio of absorbances at two selected wavelengths, one which
is an isoabsorptive point and other being the λ-max of one of the two components. The utility of this method is to calculate
unknown concentration of components of interest in a mixture containing an interfering component. CINI and RABE show an
isoabsorptive point at 273 nm in methanol. The second wavelength used is 260 nm, which is the λ-max of CINI in methanol. The
linearity was obtained in the concentration range of 4-40 μg/ml for both CINI and RABE. The mean recovery was 98.60?0.38 and
97.86?0.56 for CINI and RABE respectively. The assay result was 99.04?0.95 and 98.76?0.71 for CINI and RABE respectively. The
method was successfully applied to pharmaceutical dosage form because no interference from the mixture excipient was found.
The suitability of this method for the quantitative determination of rabeprazole sodium and cinitapride hydrogen tartrate was
proved by validation.
Patel Ankit B has completed his Master Degree at age of 23 from Ganpat University, India. He is interested in research in Pharmaceutical field. He
has presented more than 4 papers in various conferences.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals