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Development And Validation Of RP-HPLC Method For Simultaneous Estimation Of Thiocolchicoside And Dexketoprofen Trometemol In Combined Dosage Form | 10280
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

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Development and validation of RP-HPLC method for simultaneous estimation of thiocolchicoside and dexketoprofen trometemol in combined dosage form

4th International Conference and Exhibition on Analytical & Bioanalytical Techniques

Bharatkumar G. Chaudhari

Accepted Abstracts: J Anal Bioanal Tech

DOI: 10.4172/2155-9872.S1.015

Abstract
A simple, precise and rapid reverse-phase HPLC method has been developed and subsequently validated for the simultaneous estimation of thiocolchicoside and dexketoprofen trometemol from their combination drug product. The proposed RP- HPLC method utilizes a Oyster BDS C 18 , 5 μm, 250 mm ? 4.6 mm i.d. column, at ambient temperature; optimum mobile phase consisted of methanol:ammonium dihygrogen phosphate buffer (55:45, v/v), pH adjusted 7.3 with triethyl amine; effluent flow rate monitored at 1.5 mL min-1, and detection at 290 nm with UV-Visible detector. The described method was linear over the range of 10-60 μg/ml and 12.5-75 μg/ml with co-efficient of correlation, (r 2 )=0.998 and (r 2 )=0.997 for thiocolchicoside and dexketoprofen trometemol, respectively. The mean recovery was found to be 100.51?1.30% and 99.69?0.86% for thiocolchicoside and dexketoprofen trometemol, respectively. The intermediate precision data obtained under different experimental setup, the calculated value of coefficient of variation (CV, %) was found to be less than critical value. The proposed method can be useful in the quality control of bulk manufacturing and pharmaceutical dosage forms.
Biography
Bharatkumar G. Chaudhari has completed his Ph.D. at the age of 32 years from Hemchandracharya North Gujarat University. He is an Associate Professor in Department of Quality Assurance, S. K. Patel College of Pharmaceutical Education & Research, Ganpat University, Gujarat, India. He has published more than 35 papers in reputed journals and serving as reviewer in various reputed journals.
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