Direct Determination Of N-nitorsodiethanolamine (NDELA) In Ethanolamines By LC-MS-MS | 10160
Journal of Analytical & Bioanalytical Techniques
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
N-Nitrosodiethanolamine (NDELA) is produced, when an amine or amino derivative comes in contact with nitrosating
agents such as nitrous acid, nitrites or oxides of nitrogen. NDELA have long been recognized as a class of hazardous
compounds. ?UK department of trade and industry categorizes nitrosamine as more toxic in more animal species than any other
category of chemical carcinogen?. Ethanolamines are mainly used in personal-care products, detergents and one of the potential
contaminant is NDELA. As considering the toxicity of NDELA, parts per billion levels quantification of NDELA in ethanolamine
is very critical to serve customers across the globe. Various analytical methods have been developed for determination of NDELA
including GC-MS, GC-TEA, HPLC-TEA and HPLC-PHRED etc. Most of these methods require post column derivatization with
toxic chemicals, time intensive clean up procedures. Otherwise it is easy to generate false negative or positive results.
We have developed and validated a liquid chromatography and mass spectrometry (LC-MS-MS) method for direct
determination of N-nitrosodiethanolamine (NDELA) in ethanolamines. The sample is diluted with water and directly injected
to the column. Ion suppression in the MS system is minimized by using special ion exchange columns. MRM mode is used to
get the good sensitivity and repeatability of the method. LoD and LoQ of this method is 1 ppb and 5 ppb with recovery range
of 97-105%. NDELA in mono/di and triethanolamine, were quantified up to 5 ppb level. Six sigma methodologies were used to
develop and validate this method.
George Kuriakose has obtained his doctorate from Bangalore University, India and completed postdoctoral studies from GE Technology Center
(JFWTC). He is currently a lead scientist in SABIC Technology & Innovation, Analytical department, Riyadh. He has coauthored over 10 publications
in international journals. He holds two US patents. His current research interests are analytical method development in chromatography area and
specialized in liquid chromatography and mass spectrometry.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals