alexa

GET THE APP

Direct Determination Of N-nitorsodiethanolamine (NDELA) In Ethanolamines By LC-MS-MS | 10160
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Direct determination of N-nitorsodiethanolamine (NDELA) in Ethanolamines by LC-MS-MS

4th International Conference and Exhibition on Analytical & Bioanalytical Techniques

George Kuriakose and Abdulrahaman Al-hazmi

ScientificTracks Abstracts: J Anal Bioanal Tech

DOI: 10.4172/2155-9872.S1.013

Abstract
N-Nitrosodiethanolamine (NDELA) is produced, when an amine or amino derivative comes in contact with nitrosating agents such as nitrous acid, nitrites or oxides of nitrogen. NDELA have long been recognized as a class of hazardous compounds. ?UK department of trade and industry categorizes nitrosamine as more toxic in more animal species than any other category of chemical carcinogen?. Ethanolamines are mainly used in personal-care products, detergents and one of the potential contaminant is NDELA. As considering the toxicity of NDELA, parts per billion levels quantification of NDELA in ethanolamine is very critical to serve customers across the globe. Various analytical methods have been developed for determination of NDELA including GC-MS, GC-TEA, HPLC-TEA and HPLC-PHRED etc. Most of these methods require post column derivatization with toxic chemicals, time intensive clean up procedures. Otherwise it is easy to generate false negative or positive results. We have developed and validated a liquid chromatography and mass spectrometry (LC-MS-MS) method for direct determination of N-nitrosodiethanolamine (NDELA) in ethanolamines. The sample is diluted with water and directly injected to the column. Ion suppression in the MS system is minimized by using special ion exchange columns. MRM mode is used to get the good sensitivity and repeatability of the method. LoD and LoQ of this method is 1 ppb and 5 ppb with recovery range of 97-105%. NDELA in mono/di and triethanolamine, were quantified up to 5 ppb level. Six sigma methodologies were used to develop and validate this method.
Biography
George Kuriakose has obtained his doctorate from Bangalore University, India and completed postdoctoral studies from GE Technology Center (JFWTC). He is currently a lead scientist in SABIC Technology & Innovation, Analytical department, Riyadh. He has coauthored over 10 publications in international journals. He holds two US patents. His current research interests are analytical method development in chromatography area and specialized in liquid chromatography and mass spectrometry.
Top