Effects Of Li+ On Isolated Rat Heart Mitochondria | 6077
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
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Effects of Li+ on isolated rat heart mitochondria

International Conference & Exihibition On Analytical and Bioanalytical Techniques - 2010

Sergey M. Korotkov

ScientificTracks Abstracts: J Anal Bioanal Techniques

DOI: 10.4172/2155-9872.1000001

Swelling, state 4, state 3, and 2,4-dinitrophenol (DNP)-stimulated respiration as well as the membrane potential (Ψ mito ) of Li + -loaded rat heart mitochondria (LiRHM) were studied. The Li + loading of rat heart mitochondri a (RHM) resulted both in increase of passive permeability of the inner mitochondrial membrane (IMM) to H + or K + ions and in decrease of activity of the mitochondrial Na + /H + exchanger. In comparison to RHM, energized LiRHM weaker pumped out protons from the matrix and demonstrated more potent uptake of K + from an incubation medium. State 3 and 2,4-dinitrophenol (DNP)-stimulated respiration as well as the membrane potential (∆Ψ mito ) of LiRHM in KCl or LiCl media were the same that the parameters found in experiments with RHM. It is supposed that negligible influence of Li + on the respiration can be possible resulted in that Li + unlike Na + does not decrease activity of mitochondrial respiratory enzymes. It is discussed that diminution of contractile parameters of heart preparations after replacement in Ringer solution of NaCl by LiCl can be related to influence of LiCl on trigger extension in cardiac musle but not to effects of LiCl on energy supply of exitation-contraction processes in a heart.