Emerging Practices Of F19 & P31 NMR For Drug Discovery & Development | 10278
Journal of Analytical & Bioanalytical Techniques
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Phosphorus-31 & fluorine-19 NMR spectroscopies are analytical techniques based on the detection of 31P & 19F nucleus.
Because of high natural isotopic abundance and a relatively high magnetogyric ratio, these nucleuses are highly responsive
to NMR measurements and hence are being used as one of the more routine NMR techniques. The 31P & 19F nucleus also have
a spin of ?, making spectra relatively easy to interpret. Phosphorus & fluorine both are commonly found in drugs, biological
samples & prodrugs. Current poster reviews the few 31P & 19F applications which can be widely utilized in modern research.
As a first example of 19F -NMR spectroscopy, its application to the identification of metabolites of fluorine containing drugs is
discussed while 2
example of 19F NMR presents the methodology of using this nucleus to study the structure & dynamics of
As a first example of 31P-NMR spectroscopy, its usefulness to assign structures of phosphorus-containing prodrugs
is discussed because these signals are well resolved and often occur at characteristic frequencies. 2
example of 31P-NMR
spectroscopy will display the use of 31P-NMR experiment for metabolite profiling of lipophilic compounds in human serum.
Abhishek Gupta is Master?s in Biochemistry & Instrumentation and currently pursuing his doctoral thesis from Indian Institute of Technology (IIT),
Delhi, India. He is the Senior Research Scientist of Daiichi Sankyo India Pharma Private Limited in India, a subsidiary of Daiichi Sankyo-Japan, a
premier drug discovery research based organization. He is having more than 12 years of versatile experience in the field of NMR spectroscopy &
published more than 6 papers in reputed journals.
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