Enrichment Strategies For Capturing Proteins Altered By Protein Post-translational Modification | 18737
Journal of Analytical & Bioanalytical Techniques
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The extensive repertoire of protein post-translational modifications (PTMs) enables the cell to orchestrate functional
interplay of biomolecules. Thus, in order to understand the complexity of biological processes there is a need to dissect
and characterize these PTMs. However, the extensive heterogeneity of PTMs is prohibitive to global mass spectrometry since it
produces complex overlapping changes in masses. Nevertheless, we can begin to focus on PTMs by designing strategies for their
selective enrichment. Column chromatography can provide a suitable means to purify and enrich certain post-translationally
modified proteins, and a review of chromatography methods that considers their benefits and limitations will be undertaken.
Once enriched, consideration of the stoichiometry of PTM, and ultimately the functional consequence(s) of PTM will need to
Wayne Grant Carter received his Honours degree in Biochemistry and Nutrition from the University of Southampton. He then completed a PhD at the University of
Southampton studying the molecular signalling cascade elicited by insulin supervised by Dr Graham Sale. In 2003, he joined the Medical Research Council Applied
Neuroscience Group at the University of Nottingham headed by Professor David Ray. He has remained at the University of Nottingham where he is currently a
Principal Investigator and Lecturer at the University of Nottingham Medical School site within the Royal Derby Hospital, Derby. His research studies are concerned
with an understanding of protein changes that can trigger pathology. In recent years this has have focused upon hepato- and neuro- toxicological mechanisms.
Current projects include an examination of biological targets of environmental pesticides in brain, hepato- and neuro-pathology of alcohol abuse, and protein
aggregation in neurodegenerative diseases such as Alzheimer?s disease and Parkinson?s disease.
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