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Formulation And Optimization Of Proniosomes Of Famotidine: An In-vitro And Ex-vivo Study | 18766
Journal of Analytical & Bioanalytical Techniques
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The aim of study was to develop proniosomal system for famotidine, a potent H2 receptor antagonist that could efficiently
deliver entrapped drug over prolonged period of time. The Proniosomal system was formulated by selecting various ratios
of span 60 and cholesterol using coacervation-phase separation method. The formulated systems were characterized for drug
excipient compatibility studies by FTIR, vesicle size determination by particle size analyzer, % drug encapsulation, drug release
profiles, FESEM for surface morphology, XRD and vesicular stability at different storage conditions. By using this method,
the % drug loading resulted by encapsulation of proniosome was found to be 78-89%. Increase in cholesterol and surfactant
concentration increases encapsulation efficiency but further increment decreases encapsulation.
drug release studies
showed prolonged release of entrapped famotidine. The highest % cumulative drug release was achieved in formulation FAM2
(96%) in 24 hr. The
data of release of famotidine from proniosomal formulations have shown significantly increase
percent release & flux with comparison to same dose of marketed preparation of famotidine. Stability studies were carried out
at refrigerated conditions, higher drug retention was observed. It is evident from this study that proniosomes are a promising
prolonged delivery system for famotidine and have reasonably good stability characteristics.
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