Journal of Analytical & Bioanalytical Techniques
Open Access

Abstract

1, 4-Dioxane, a toxic by-product may be formed during the ethoxylation of fatty alcohol. A simple and rapid method using gas chromatography with flame ionization detector (GC-FID) was developed to detect-1, 4-dioxane in commercial palm-based fatty alcohol ethoxylate (FAEO). This method involved spiking of 1, 4-dioxane into FAEO samples, and directly injecting the spiked samples into GC-FID. The method was validated according to the ICH harmonized tripartite guideline. The calibration curves for 1, 4-dioxane showed good linearity with correlation coefficient of 0.9999. The accuracy of the method was indicated by recovery obtained for spiked 1, 4-dioxane samples at 5 levels of spiking, i.e. at 30, 60, 100, 200 and 500 �?¼g/g, where recoveries were within 99 â�?�? 105% with relative standard deviation (RSD) of less than 4.0%. The RSD values of the intra-day and inter-day precision were less than 1.0%. The limit of detection and quantification was 10 �?¼g/g and 30 ug/g, respectively. The identity of 1, 4-dioxane recovered from the palm-based fatty alcohol ethoxylate was confirmed by a GC-mass spectrometer detector.

Biography

Bonnie Tay-Jones Yen Ping received her Master of Science degree (organic chemistry) from University Putra Malaysia, Serdang, Malaysia. She is currently a principal research scientist attached to Quality and Environment Assessment Unit, Advanced Oleochemical Technology Division, Malaysian Palm Oil Board. Presently, she is actively involved in research (method development work to detect toxic contaminants/by-products) for the local oleochemical producers. She was the main author of several publications in reputed journals on topics relating to gel permeation chromatography analyses for palm-based polyols, chemometrics, basic oleochemical compositional analyses and method development for detection of contaminants/by-products in palm-oil derived oleochemicals.

Email: bonnie@mpob.gov.my