Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar

GET THE APP

Identification And Characterization Of New Drugs Using Mass Spectrometry | 6034
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Identification and Characterization of New Drugs Using Mass Spectrometry

International Conference & Exihibition On Analytical and Bioanalytical Techniques - 2010

K Srinivasa Rao

ScientificTracks Abstracts: J Anal Bioanal Techniques

DOI: 10.4172/2155-9872.1000001

Abstract
Mass spectrometer can be used in 3 principal ways: firstly, to measure the molecular weights with very high accuracy; from these can be deduced exact molecular formulae. Secondly, to detect within a molecule the places at which it prefers to fragment; from this can be deduced the presence of functional groups within the molecule. And thirdly, as a method for identifying drug molecules by comparison of their mass spectra with libraries of digitized mass spectra of known compounds. Molecular ion gives highly useful information about the identity of the drug molecule. Fragmentation pattern gives further information about the structure of the drug molecule. All fragment ions are, however, not of equal significance to assign the structure to a compound. Intensity of the molecular ion peak in a mass spectrum depends on the type of the compound. Mass spectra cannot be interpreted if they contain any misinformation. Unfortunately, even referred journals and carefully edited collections of the standard spectra sometimes contains spectra that fail to meet this criterion. Some compounds e.g., alcohols may fail to give a visible molecular ion peak. Judging whether or not a mass spectrum is credible is sometimes the most critical step in its interpretation. Most EI mass spectrometers in use today lack sufficient resolving power to provide accurate mass measurement for the determination of elemental composition. However, the elemental composition of an ion can sometimes be determined from the ratios of the peak intensities of the isotope peaks for that ion to the intensity of the nominal mass peak. Some typical features may be helpful i.e., if the M+2 peak of the parent ion looks larger than the M+1 peak, the compound might contain S,Cl or Br. When there is a larger gap and a peak at 127, iodine may be present. The intensity of the M+1 peak can be used to know the number of carbons well as nitrogen atoms. In the absence of nitrogen, the maximum number of carbaon atoms can be calculated by dividing the relative intensity of the M+1 peak by 1.1. Thus, e.g., a molecule with 12 carbon atoms will display a M+1 peak of 13.2 per cent. In case nitrogen is present its contribution to the M+1 peak will amount of 0.4 X number of nitrogen atoms. This quantity must be subtracted from the measured relative intensity of the M+1 peak to know the number of carbon atoms. When in a compound Cl, Br, S or Si is present loss of a proton from the M+2 is likely to enhance the intensity of the M+1 peak. The number of nitrogen atoms present can be deduced with the help of nitrogen rule. In this talk we will address, how to identify different drug molecules using mass spectrophomter with relevant examples.
Biography
Top