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Molecular recognition processes are predicted to become the basis of all advanced separation techniques.
In solution and recently also in suspension ligand-receptor interactions can be studied using methods of
high-resolution (HR) suspended-state NMR spectroscopy, for example by employing the nuclear Overhauser
enhancement (NOE) technique or by saturation transfer difference (STD) NMR. We have utilized 2D NOESY
techniques together with suspended-state
H-NMR spectroscopy to characterize the interactions between silica
based chromatographic supports and low-molecular weight compounds.
We will show that suspended-state
H NMR spectroscopy and 2D NOESY experiments can be efficiently
used to observe interactions between the analyte and the stationary phase as well as the influence of chemical
modifications of the silica and the contribution of solvent effects.
The difference NMR technique provides valuable results concerning ligand-receptor interactions by using
saturation transfer processes (STD NMR) to detect intermolecular spin diffusion of a macromolecule that strongly
interacts with a small ligand. This experiment can be applied to systems with only a small amount of receptor
molecules and in most cases with a huge excess of ligand.
Thus, 2D NOESY and saturation transfer difference (STD) NMR experiments can provide valuable
information for the design and implementation of novel, task-specific or tailored stationary phases.
Klaus Albert, professor of chemistry at the University of Tuebingen (Germany) since 1996, performed his studies in chemistry at the
Universities of Stuttgart and Tuebingen. He received his diploma in 1973 and his Dr. rer. nat. in 1976 from the University of Tuebingen.
His research interests include natural product chemistry, stationary chroma-tographic phases, molecular recognition processes, and
the hyphenation of chroma-tographic separation methods with NMR spectroscopy. His current number of peer-re-viewed publications
is 260. Since 1987 he is Visiting Associate Professor at the Department of Biochemistry at Tufts University, Boston, USA. In 1999
he was stipend of the Japanese Society for the Promotion of Science. In 2000 he received the ?Jubilee Silver Medal? of the Brit
Chromatographic Society and in 2005 the ?Andrzej Waksmundzki Medal? of the Polish Academy of Sciences.
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