LC-MS Method Development For The DPP-IV Inhibitor Screening | 5994
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

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LC-MS Method Development for the DPP-IV Inhibitor Screening

2nd International Conference on Analytical & Bioanalytical Techniques

Lei Fu, Jingjing Liu and Shawn Shen

Accepted Abstracts: J Anal Bioanal Techniques

DOI: 10.4172/2155-9872.S1.05

D ipeptidyl peptidase IV (DPP-IV) is an enzyme of considerable biomedical interest. It plays an important role in glucose homeostasis through proteolytic inactivation of incretin hormones, primarily glucagon like peptide-1 (GLP-1) which is critical in sugar balance. Traditionally, the DPP-IV inhibitors were evaluated using fl uorogenic or chromogenic methods. However, it is limited by the selection of substrates since the cleavage product of the substrates must be fl uorogenic or chromogenic. In addition, it requires that the candidate inhibitors should be of no fl uorescence or chromophorous.
Professor Lei Fu received his Ph.D. degree in Chemistry from Stanford University. After a one-year postdoctoral research at Stanford, he joined Pharmacyclics Inc., California in 1998, conducting drug discovery and development research on anti-cancer and anti-cardiovascular diseases. Dr. Fu has been a Professor of Medicinal Chemistry at Shanghai Jiao Tong University since 2006. His principal research interests are 1) drug discovery and development; 2) traditional Chinese Medicines as botanical cosmeceuticals; 3) medical devices as targeted drug delivery systems and 4) chemical induction of hypothermia. He was a visiting scholar in the Department of Chemistry, Stanford University in 2009.