Lead Molecules For Molecular Medicine And Omic Studies | 6089
Journal of Analytical & Bioanalytical Techniques
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In this paper, new compounds synthesised during the last three and a half decades
will be presented. These molecules have become intertwined with omic studies
and could serve as leads for molecular medicine. Six such compound classes will
be discussed here.
prepared have been shown to be potent
for human cancer / tumour cells, which had stopped taking
up further radiation.
New nitrophenyl azides prepared have been shown to exhibit inhibitory activity
In the former, these showed �2, 4-D�
like activity. The corresponding amines were used to synthesise biologically
This work has been cited in a recent
5, 6- Dimethoxybenzofuroxan, which exists in two rapidly equilibrating degenerate
has been shown to possess antifungal activity against
and other fungi. Based on this benzofuroxan, a new indoloquinoxaline dioxide has
been synthesised which could show antibacterial activity.
A short synthesis of Pyrroloquinoline quinone, P. Q. Q. (Methoxatin) has been
developed. This compound is considered to be a new vitamin to prevent heart
attacks and strokes.
New homo and hetero bifunctional crosslinkers have been developed. Similar
reagents could be designed based on P.Q.Q., which will be employed for
proteomics. Cholesterol /steroid photolabels are also being prepared for lipidomics.
Dehydrodivanillin, a natural product has been used to prepare antifungal 1, 2,
3-triazoles using the Click reaction.
studies are being undertaken for all the above compounds to
unravel the underlying biological mechanisms. This has a great potential in the area
of omic studies and for developing better diagnostic tools for molecular medicine.
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