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Lead Molecules For Molecular Medicine And Omic Studies | 6089
ISSN: 2155-9872
Journal of Analytical & Bioanalytical Techniques
Open Access
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In this paper, new compounds synthesised during the last three and a half decades
will be presented. These molecules have become intertwined with omic studies
and could serve as leads for molecular medicine. Six such compound classes will
be discussed here.
�
Methoxyisoxazole quinones
prepared have been shown to be potent
radiosensitisers
in vitro
for human cancer / tumour cells, which had stopped taking
up further radiation.
�
New nitrophenyl azides prepared have been shown to exhibit inhibitory activity
against
Crotalaria
juncea
(Jute) and
E
.
coli.
In the former, these showed �2, 4-D�
like activity. The corresponding amines were used to synthesise biologically
interesting 9-Aryl-9H-Purine-6-amines.
This work has been cited in a recent
patent.
�
5, 6- Dimethoxybenzofuroxan, which exists in two rapidly equilibrating degenerate
forms
has been shown to possess antifungal activity against
Candida
albicans
and other fungi. Based on this benzofuroxan, a new indoloquinoxaline dioxide has
been synthesised which could show antibacterial activity.
�
A short synthesis of Pyrroloquinoline quinone, P. Q. Q. (Methoxatin) has been
developed. This compound is considered to be a new vitamin to prevent heart
attacks and strokes.
�
New homo and hetero bifunctional crosslinkers have been developed. Similar
reagents could be designed based on P.Q.Q., which will be employed for
proteomics. Cholesterol /steroid photolabels are also being prepared for lipidomics.
�
Dehydrodivanillin, a natural product has been used to prepare antifungal 1, 2,
3-triazoles using the Click reaction.
In vivo
and
in vitro
studies are being undertaken for all the above compounds to
unravel the underlying biological mechanisms. This has a great potential in the area
of omic studies and for developing better diagnostic tools for molecular medicine.
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