alexa

GET THE APP

Lead Molecules For Molecular Medicine And Omic Studies | 6089
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Lead Molecules for Molecular Medicine and Omic Studies

International Conference & Exihibition On Analytical and Bioanalytical Techniques - 2010

S. V. Eswaran

ScientificTracks Abstracts: J Anal Bioanal Techniques

DOI: 10.4172/2155-9872.1000001

Abstract
In this paper, new compounds synthesised during the last three and a half decades will be presented. These molecules have become intertwined with omic studies and could serve as leads for molecular medicine. Six such compound classes will be discussed here. � Methoxyisoxazole quinones prepared have been shown to be potent radiosensitisers in vitro for human cancer / tumour cells, which had stopped taking up further radiation. � New nitrophenyl azides prepared have been shown to exhibit inhibitory activity against Crotalaria juncea (Jute) and E . coli. In the former, these showed �2, 4-D� like activity. The corresponding amines were used to synthesise biologically interesting 9-Aryl-9H-Purine-6-amines. This work has been cited in a recent patent. � 5, 6- Dimethoxybenzofuroxan, which exists in two rapidly equilibrating degenerate forms has been shown to possess antifungal activity against Candida albicans and other fungi. Based on this benzofuroxan, a new indoloquinoxaline dioxide has been synthesised which could show antibacterial activity. � A short synthesis of Pyrroloquinoline quinone, P. Q. Q. (Methoxatin) has been developed. This compound is considered to be a new vitamin to prevent heart attacks and strokes. � New homo and hetero bifunctional crosslinkers have been developed. Similar reagents could be designed based on P.Q.Q., which will be employed for proteomics. Cholesterol /steroid photolabels are also being prepared for lipidomics. � Dehydrodivanillin, a natural product has been used to prepare antifungal 1, 2, 3-triazoles using the Click reaction. In vivo and in vitro studies are being undertaken for all the above compounds to unravel the underlying biological mechanisms. This has a great potential in the area of omic studies and for developing better diagnostic tools for molecular medicine.
Biography
https://www.dhgatewatches.net
Top