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Lead Molecules For Molecular Medicine And Omic Studies | 6089
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
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Lead Molecules for Molecular Medicine and Omic Studies

International Conference & Exihibition On Analytical and Bioanalytical Techniques - 2010

S. V. Eswaran

ScientificTracks Abstracts: J Anal Bioanal Techniques

DOI: 10.4172/2155-9872.1000001

In this paper, new compounds synthesised during the last three and a half decades will be presented. These molecules have become intertwined with omic studies and could serve as leads for molecular medicine. Six such compound classes will be discussed here. � Methoxyisoxazole quinones prepared have been shown to be potent radiosensitisers in vitro for human cancer / tumour cells, which had stopped taking up further radiation. � New nitrophenyl azides prepared have been shown to exhibit inhibitory activity against Crotalaria juncea (Jute) and E . coli. In the former, these showed �2, 4-D� like activity. The corresponding amines were used to synthesise biologically interesting 9-Aryl-9H-Purine-6-amines. This work has been cited in a recent patent. � 5, 6- Dimethoxybenzofuroxan, which exists in two rapidly equilibrating degenerate forms has been shown to possess antifungal activity against Candida albicans and other fungi. Based on this benzofuroxan, a new indoloquinoxaline dioxide has been synthesised which could show antibacterial activity. � A short synthesis of Pyrroloquinoline quinone, P. Q. Q. (Methoxatin) has been developed. This compound is considered to be a new vitamin to prevent heart attacks and strokes. � New homo and hetero bifunctional crosslinkers have been developed. Similar reagents could be designed based on P.Q.Q., which will be employed for proteomics. Cholesterol /steroid photolabels are also being prepared for lipidomics. � Dehydrodivanillin, a natural product has been used to prepare antifungal 1, 2, 3-triazoles using the Click reaction. In vivo and in vitro studies are being undertaken for all the above compounds to unravel the underlying biological mechanisms. This has a great potential in the area of omic studies and for developing better diagnostic tools for molecular medicine.