Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar


Liquid Chromatography And Mass Spectrometry In Characterization Of Metabolites | 5939
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences

3rd International Conference on Analytical Chemistry

Prague, Czech Republic
Google Scholar citation report
Citations : 4454

Journal of Analytical & Bioanalytical Techniques received 4454 citations as per Google Scholar report

Journal of Analytical & Bioanalytical Techniques peer review process verified at publons
Indexed In
  • CAS Source Index (CASSI)
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Academic Journals Database
  • Open J Gate
  • Genamics JournalSeek
  • JournalTOCs
  • ResearchBible
  • China National Knowledge Infrastructure (CNKI)
  • Ulrich's Periodicals Directory
  • Electronic Journals Library
  • RefSeek
  • Directory of Research Journal Indexing (DRJI)
  • Hamdard University
  • OCLC- WorldCat
  • Scholarsteer
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Euro Pub
Share This Page

Liquid chromatography and mass spectrometry in characterization of metabolites

3rd International Conference and Exhibition on Analytical & Bioanalytical Techniques

Selvan Ravindran

ScientificTracks Abstracts: J Anal Bioanal Techniques

DOI: 10.4172/2155-9872.S1.007

Liquid chromatography coupled with mass spectrometry serves as a powerful tool to characterize the structure of drugs and metabolites. Identification of the structure of metabolites during the drug discovery and development helps to optimize the structure of the molecules. Characterization of the structure of compounds by X-ray crystallography and nuclear magnetic resonance spectroscopy need compounds of high purity in solid or liquid form. Single compound can be analyzed by X-ray crystallography or Nuclear magnetic resonance spectroscopy but in biological processes when a drug is converted to many metabolites analysis by either of these techniques is cumbersome. In such instances while many metabolites are present in the system liquid chromatography interfaced with mass spectrometry will be beneficial. Liquid chromatography separates the drugs and metabolites based on the polarity of the compounds and mass spectrometry detector identifies and differentiates the metabolites based on the molecular weight. Metabolites with same masses are identified by their retention times and fragmentation spectra. Fragmentation spectrum (ie MS2 or MS/MS) of the identified metabolite provides valuable information to characterize the structure of the metabolites. In the present study few important drugs available in the market are subjected to biological treatment and the resultant metabolites are characterized using liquid chromatography and mass spectrometry. Metabolites were also quantified based on the drug metabolite ratio using liquid chromatography. Thus liquid chromatography in tandem with mass spectrometry provides an ideal platform to identify, quantify and characterize the structure of metabolites.

Selvan Ravindran is a Senior Research Scientist in Sai Life Sciences Limited, Pune, India. He received his Ph.D degree from Indian Institute of Technology (Chennai). He did his postdoctoral studies in University of Texas Medical Branch, USA and University of Arizona, USA. He also worked as a Biotransformation Scientist in Biocon Bristol Myers and Squibb Research Centre in Bangalore. His major areas of research interests are Biotransformation (Metabolite identification using liquid chromatography and mass spectrometry), Bioanalysis and DMPK (Drug Metabolism and Pharmacokinetics). He has published many research papers in reputed journals and presented more than 20 papers in national and international conferences.