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Modified Synthesis And Characterization Of Benzodiazepines Compounds | 10305
ISSN: 2155-9872
Journal of Analytical & Bioanalytical Techniques
Open Access
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The benzodiazepines are the prototypic anti-anxiety agents. In the present research work chloroacetyl chloride was treated
with (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone in presence of toluene to get 2-chloro-N-[4-chloro-2-
(2-chloro-benzoyl)-phenyl]-acetamide, which was treated with sodium iodide to get 2-iodo-N-[4-chloro-benzoyl)-phenyl]-
acetamide and then with hydrochloricacid to get 6-chloro-2-chloromethyl-4-(2-chlorophenyl)-quinazoline-3-oxide which was
converted to 7-chloro-5-(2-chloro-phenyl)-2-oxo-2-3dihydro-1Hbenzo[e][1,4] diazepin-4-ol anion and this has been treated
with acetic anhydride to get acetic acid 7-chloro-5-(2-chloro-phenyl)-2-oxo-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl ester ,
this was treated with potassium carbonate and methanol to get Lorazepam and finally refluxed with toluene to get 6-chloro-4-(2-
chloro-phenyl)-quinazoline-2-carbaldehyde. The yield of all synthesized derivatives was found to be in the range of 55-97%. TLC,
IR and NMR spectral studies confirmed structure of derivatives. The synthesized derivatives were screened for their anxiolytic
activity by determining time spent in open arm, time spent in closed arm and number of entries in open arm in mice by elevated
plus maze method. Derivative C9 showed significant activity when compared to that of control.
Biography
Shruti Tongda is a second year student of Bachelor of Pharmacy at Rajasthan University of Health Science, Jaipur. She is student of Geetanjali
Institute of Pharmacy, Dabok, Udaipur. She is interested in research field and has attended various research oriented conferences and seminars.
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