A large body of evidences implies that the measurement of isoprostanes is reliable
biomarkers of oxidative stress. Isoprostanes are families of PGF-like compounds
derived by non-enzymatic oxidation of fatty acids with two double-bonds or more.
Of these, PGF2-like compounds specifically derived from arachidonic acid have
received the most attention because of their availability at major research laboratories
with long lasting interest in prostaglanding metabolism in the United States. Recent
advancement in the analytical field has led to discovery of an array of other PGF-
like compounds derived from linoleic acid, linolenic acid, eicosapentaenoic acid and
docosahexaenoic acid. The aim of this presentation is to shed a light on the natural
history of PGF-like compounds since their discovery by Nugteren in 1975, discuss
recent achievement and address new directions in the filed.
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