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�New� Drugs & International Regulatory Mechanisms | 6028
Journal of Analytical & Bioanalytical Techniques
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�The big players� continue to dominate the medicinal scene and such parameters are
important when �incurable� diseases set in. Prevention rather than �treatment� of diseases
needs to be emphasized. Interactions between hitherto undetected disease causing
proteins (�small players�) are being targeted, whereby newer and better drugs are
awaited in the forthcoming era of personalized medicine.
Anti-fungals based on �Click� reaction have been developed by the author. Fift
years since the discovery of the last vitamin, Pyrroloquinoline quinone (PQQ) is now
recognized as the 14
vitamin. To be useful as a vitamin, it has to available at low cost.
e author�s work on �true nitrene� based homo and hetero bifunctional crosslinkers for
proteomics and lipidomics could be useful for chemical crosslinking-mass spectrometry
based rapid and reliable high throughput screening (HTS) of large number of samples
routinely. Soluble Fullerenes
and SWCNT developed in my laboratory have been shown
to be compatible with blood for nano-drug delivery.
Norms for drug approvals becoming very stringent worldwide, discovery of new drug
entities has now become very diffi
cult. As ways are found for overcoming these, many
issues arise, which need to be adjudged in an equitable and fair manner. Serving as a
�Local Commisioner� in cases of drug fi
rms at an international level has been a learning
experience for the author. Th
e use of modern instrumentation for regulatory purposes is
to be strongly advocated. Open Source Drug Discovery (OSDD), a laudable initiative has
also provided the author much needed stimulus.
Dr S. V. Eswaran, Head, Chemistry Department and Dean, (Academics), St. Stephen?s College, University of Delhi, Delhi and has taught there for 42 years. Served as Principal, Deshbandhu College, Delhi for two years and as a member for many national committees. Ph. D., Delhi, 1973; Post-Doc. Max Planck, Munich, 1976-77; Heidelberg, Karlsruhe, 1984; Goettingen, 1997, Germany; TU, Delft, Netherlands,1990; Ohio State University, 1997; Brown University, 2006, USA. Best teacher award, 2007; distinguished teacher award, 2009; DADD fellowship, 1976-77. Published 60 papers, granted many patents and supervised 4 Ph. D. and 21 M. sc/ M. Tech.. thesis.
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