RP HPLC Determination Of Elvitegravir In Rat Plasma Using Ionic Liquid Based Dispersive Liquid Liquid Microextraction Method And Its Application To Pharmacokinetic Studies | 18759
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
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RP HPLC Determination of Elvitegravir in rat plasma using ionic liquid based dispersive liquid liquid microextraction method and its application to pharmacokinetic studies

5th International Conference and Exhibition on Analytical & Bioanalytical Techniques

Aditya, Dande Payal R, Deshpande Shirish and R Nageswara Rao

Accepted Abstracts: J Anal Bioanal Tech

DOI: 10.4172/2155-9872.S1.019

Dispersive Liquid Liquid Micro Extraction Technique (DLLME) is a new method which is fast, accurate and less time consuming, utilizing minimum amount of organic solvents in extraction of drugs from Biological Media. This DLLME was combined with environment friendly designer solvent known as ionic liquid, which acts as an extractant in recovering drug from plasma. This IL-DLLME process was used to extract Antiviral drug elvitegravir from rat plasma. 1-butyl-3- methylimidazolium hexafluorophosphate (BMIMPF6) was used as the ionic liquid in the present investigation. Methanol was used as an enrichment factor to increase the % recovery of the drug. In comparison to protein precipitation, there is a threefold enhancement in limit of detection. This IL-DLLME process is further optimized in various parameters like ionic liquid: methanol ratio, NaCL concentration etc. The method was showing a linearity in the range of 0.05-10.0 μg/ml with correlation coefficient of 0.9993. The limit of detection was found to be 0.05 μg/ml and the limit of quantification was found to be 0.18 μg/ml. The relative standard deviation was found to be 1.37%. The method was validated as per ICH guidelines and was applied to pharmacokinetic studies in rats.