Journal of Analytical & Bioanalytical Techniques
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Hydrazide-/hydrazones have been demonstrated to possess antibacterial, anticonvulsant and antitubercularactivities. These
observations led us to synthesize novel hydrazide-hydrazones and to investigate their possible antitumor activities. It
has been reported in the literature that hydrazide-hydrazones can give the corresponding hydrazide and aldehyde metabolites
whereas the related hydrazides are known to yield carboxylic acids via hydrolytic route. Based on this knowledge, one can expect
hydrazide-hydrazones, which were obtained from the reaction of cyanoacetyl hydrazine with benzaldehyde were also designed
as possible anti-tumor agents. Thus, in this work we described the uses of the hydrazide-hydrazone derivative 3 obtained through
the reaction of cyanoacetyl hydrazine with benzaldehyde to synthesis pyridazine, 1,2,3-triazole and pyrazole derivatives The
newly synthesized products were screened as antitumor agents on the
growth of three human tumor cell lines representing
different tumor types, namely, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-
268). It was found that some of these compounds showed inhibitory effects on the three cell lines, indicating their potential use
in the development of oncology products.
Wagnat W. Wardakhan, has completed her Ph. D. in 1996. She got her full Professor degree in 2010. At the moment she is occupying the position
of the head of pharmaceutical Organic Chemistry Department at the National Organization for Drug Control & Research, Giza, A. R. Egypt. She
published more than 50 publications in an International Journals.
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