Standardization And Preclinical Studies On 'Kakadshringi': Leaf Galls Used In Ayurvedic System Of Medicine | 6042
Journal of Analytical & Bioanalytical Techniques
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The growing demand of crude drugs (raw materials and their products) by
populations is forcing to develop standards for quality control and to evaluate
the health climes. Much more studies in this aspect have been done on plant
originated crude drugs/raw materials. Meager evaluation is available considering
animal originated raw materials. Use of insect galls as medicine is not new but
evaluation of such materials is unique. The ethnobotanical and Ayurvedic literature
indicates that �Kakadshringi� leaf galls are used for the treatment of diarrhoea.
The leaf galls occurring on botanically three different plant species viz.
Stew. ex Brindis,
commerced in trade. These samples were standardized using pharmacognostic and
phytochemical parameters to establish identification markers. To investigate the text
clime, antidiarrheal activity was evaluated using animal modal. The result suggested
that ethanol extract of
and loperamide, a standard antidiarrheal drug
showed significant reduction in fecal output in castor oil and magnesium sulphate
induced diarrhoea and castor oil induced intraluminal fluid accumulation. Also it
inhibited dose dependently (100-500 mg/kg) the intestinal propulsion of charcoal
meal in normal and barium chloride induced changes in gastrointestinal tract. The
ethanol extract of
has antidiarrhoeal, antisecretory and antipropulsive
activities and it may be due to their high phenolic and tannin content. Our studies
can be equated to �Kakadshringi� and its indication for
the treatment of diarrhoea.
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