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The International Diabetes Federation estimates that 285 million people around the
world have diabetes. This total is expected to rise to 438 million within 20 years.
Each year a further 7 million people develop diabetes. Around 90 % of the diabetes
patients are found to suffer from type 2 diabetes mellitus. Many patients suffering
from type 2 diabetes require treatment with more than one antihyperglycemic drug
to achieve optimal glycemic control. The combination of metformin hydrochloride �
Biguanides with any one of the Sulphonylureas - glipizde, gliclazide, glibenclamide,
glimperide or with Alpha glucosidase inhibitors - voglibose can present daunting
challenges to analytical scientist during HPLC analysis. This talk will drill into the
details of method development and discuss the common problems encountered as
in case of metformin & sulphonyl urea � vast differences in their polarity, pk
extraction from the biological fluids very difficult which may lead to low recovery and
low sensitivity. Differences based on their protein binding characteristics - sulphonyl
urea strongly bound to proteins lead to low recovery. Strategies to optimize the
mobile phase, extraction procedures in biological fluids, to increase the recovery
by disrupting drug- protein binding will be highlighted. Challenges to improve the
detection of low UV absorbing component as in the case of voglibose will be dealt.
These methods are inevitable to monitor a population of diabetic patients who take
several diabetic medications without changing HPLC colums.
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