Journal of Analytical & Bioanalytical Techniques
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For, the last fifty year�s nuclear magnetic resonance spectroscopy, generally referred as nmr, is one of the most versatile
technique for elucidation of structure of organic compounds. Among all available spectrometric methods, NMR is the only
technique which offers a complete analysis and interpretation of the entire spectrum. Due to improved experimental technology
and novel approaches, over the last decade Nuclear magnetic resonance (NMR) has shown a tremendous progress. Generally,
NMR spectroscopy makes use of three approaches; those are one dimension (1D), two dimensions (2D) and multiple dimensions
(MD). Usually, the first approach of 1D-NMR (
P, DEPT, INEPT etc.) generates good information about the
structure of simple organic compounds, but in case of larger molecules the 1D-NMR spectra are generally overcrowded. Hence,
the second approach of 2D-NMR (COSY, DQFCOSY, MQFCOSY, HETCOR, HSQC, HMQC, HMBC, INADEQUATE, TOCSY,
NOESY, HOESY, DOSY, ROESY, EXSY etc.) is used for the further larger molecules, but 2DNMR spectra also becomes complex
and overlapping when used for further very large molecules like proteins. Hence, so as to achieve high resolution and reduced
overlapping in spectra of very large molecules, 3D-NMR or MD- NMR (Homonuclear and Heteronuclear) are generally used.
Neeraj Kumar Fuloria has completed his PhD in Pharmaceutical Chemistry at the age of 35 years from Uttar Pradesh Technical University, India. He is the Head of Department of M. Pharm. (Quality Assurance), in Anuradha College of Pharmacy, Amravati University, M.H., India. He has published more than 18 papers in reputed journals and serving as an editorial board member of Journals like The Clinical Research Plus Magazine and Bulletin of Pharmaceutical Research of repute.
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