ZSM-5 Based Chromatographic Adsorbents As A Potential Tool For Biomarkers Detection | 10224
Journal of Analytical & Bioanalytical Techniques
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Preliminary research that have been conducted and numerous works published by other research groups confirm the existence
of small molecular cancer biomarkers (SMCBs). However, the origin of these metabolites (that can serve as clinical disease
markers) still remains unknown. Clear understanding of how and where SMCBs are generated in a human organism is of urgent importance.
Novel adsorptive materials with polymer mixed with zeolites are under investigation and give promising results due to
improvement of adsorptive coatings. For instance, PDMS/zeolite membranes, rarely reported for filtration purpose, to the best of
our knowledge, in our current study are used for the first time as adsorbents for preconcentration and extraction of volatile and
semivolatile compounds from complex matrices for further GC-MS analysis.
As found in preliminary study, composite of zeolites with polymer base (Tenax TA, PDMS) possess higher adsorption
capacity, better retention of the adsorbed compounds, enhanced diffusion and respectively equilibration times. Multi compound
test of PDMS doped with 10% ZSM-5 shown that addition of zeolite extends not only improves the adsorption capacity of PDMS
but spectra of adsorbed analytes (+highly volatile, +hydrophilic) that are not usually adsorbed or effectively retained in PDMS alone.
Current work will describe process of the investigation of cancer cell cultures
. Using thin-film microextraction
(TFME) coupled with a gas chromatography mass spectrometry (GC-MS) analytical method, we are conducting the search of
in the several types of cell cultures.
Shigemi Goda has completed her B.Sc. at the age of 22 years from the University of Kitakyushu and now she is the master student in the same
University. Her research interests include the detection of small molecular markers of cancer from the
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