alexa Abstract | Abdominal Stereotactic Body Radiotherapy: Local Control and Correlation to Biologically Equivalent Dose
ISSN:2167-7964

OMICS Journal of Radiology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Aim: We conducted a retrospective study to report on the outcome and toxicity of stereotactic body radiotherapy (SBRT) and to analyze the correlation of local control (LC) and biological equivalent dose (BED) of patients treated with SBRT for upper abdominal lesions.

Methods: Patients who completed stereotactic radiotherapy treatment between 05/2007 and 03/2012 were enrolled into the analysis. Different fractionation regimens depending on the dose to organs at risk (OAR) were given. The primary endpoint was LC determined on imaging studies. Toxicities were classified according to CTCAE v4. Physical dose was converted into BED (α / β = 10 Gy) and a tumor control probability model (TCP) was used for dose-response relationship. For outcome analyses the Kaplan-Meier method and log rank tests were used.

Results: Forty-two patients were treated with SBRT. Thirty-three patients with 39 lesions were evaluable for further analysis with a median follow-up of 15.2 months. Lesions were located in liver (n = 28), hepatic hilum (n = 8), nodal (n = 2), adrenal (n = 2) and pancreatic head (n = 1). Local failure was observed in 7 lesions at a mean time of 7.3 months (range, 1.5 - 17.9) resulting in a LC rate of 83% at one year and 63% at two years. No significant difference for intra- vs extrahepatic lesions was observed. Lesions treated with a BED ≥ 59.5 Gy had a better LC vs. lesions treated with a BED < 59.5 Gy (88% vs. 68%, p = 0.027). Median overall survival was 14.5 months (2 - 32.5). Observed toxicities were mild (grade 2 in 4 patients, grade 3 in 1 patient).

Conclusion: Upper abdominal SBRT is well tolerated and results in excellent local control if BED is ≥ 59.5 Gy. We therefore propose to aim for doses at or above this BED.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Simon Kirste, Hans Trautsch, Marc-Benjamin Messmer, Rolf Wiehle, Hans-Christian Rischke, Felix Momm, Anca-Ligia Grosu and Thomas B. Brunner

Keywords

Stereotactic radiotherapy, Abdominal, Biological equivalent dose, Liver, Toxicity, Abdominal Radiology, Radiography

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords