alexa Abstract | Management Of Unexpected Peritoneal Metastases With Primary Colorectal Cancer Using Second-Look Surgery With HIPEC

Cancer Surgery
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Background: Peritoneal metastases (PM) will be unexpectedly present in approximately 10% of colorectal cancer patients having primary cancer resection. In the past this was considered to be an incurable condition with a terminal outcome. In patients determined to have peritoneal dissemination at the time of resection, the intervention was considered palliative. Recently, long term benefit from definitive treatment of PM with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has become a reality. These treatments are now appropriate for primary appendiceal and colorectal cancer determined to have PM at the time of resection.

Methods: Modifications of the initial management of colorectal cancer patients found upon exploration to have PM are explored in this manuscript. In these patients, not only the primary cancer but also the PM must be optimally treated.

Results: The presentation of the primary colon or rectal cancer as asymptomatic, bleeding, obstructed or perforated is important in treatment planning. The surgical approach must facilitate subsequent interventions to definitely treat PM. Procedures performed on the primary cancer are designed to minimize tumor cell entrapment. These patients usually have short course of systemic chemotherapy prior to repeat intervention with HIPEC. Conclusion: CRS and HIPEC must be integrated into the management of colorectal cancer patients who have PM identified unexpectedly at the time of primary cancer resection. Major resections in the absence of HIPEC should not occur in these patients in order to preserve an intact peritoneum as the first line of defense against PM and avoid tumor cell entrapment in subsequent CRS and HIPEC procedures.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Paul H. Sugarbaker and Olivier Glehen

Keywords

Peritoneal metastases, Peritoneal carcinomatosis, Colorectal cancer, HIPEC, Cytoreductive surgery, Perioperative chemotherapy, Second-look surgery, Colon Cancer Surgery

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords