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Research Article Open Access
Objective: To analyze starting time (early versus late) and duration of caffeine treatment and its possible
influence on neurodevelopmental (ND) outcome in very preterm infants.
Hypothesis: Early initiation of caffeine treatment with longer duration of treatment may significantly improve ND outcome in very preterm infants.
Design: Retrospective cohort study.
Setting: Level III Neonatal Intensive care Unit (NICU) and out-patient NICU follow-up clinic of an academic medical center in New York City.
Participants: A total of 146 inborn infants with gestational ages (GA) of 23-32 weeks who received caffeine treatment were included in this study with the following exclusion criteria: incomplete clinical data, insufficient ND follow-up and transfer of infants to other facilities.
Interventions: Information on the administration of Caffeine Citrate injection USP and Caffeine Citrate oral solution (20 mg/ml equivalent to 10 mg caffeine base) including duration of treatment were obtained from individual chart reviews.
Primary outcome measure: Normal and adverse (mild/moderate, severe) ND outcome.
Results: Duration and starting point (early versus late) of caffeine treatment were not associated with ND
outcome; adjusted for GA, head ultrasound (HUS) results and gender. The only significant predictor of ND outcome
Conclusion: Gestational age (GA) seems to have more of an influence on ND outcome than caffeine citrate
treatment regardless of duration (i.e., dose) and onset (early versus late) of such treatment.
Caffeine treatment, Prematurity, Neurodevelopmental outcome, Birth Complications, Breastfeeding, Bronchopulmonary Dysplasia, Feeding Disorders, Gestational diabetes, Neonatal Anemia, Neonatal Breastfeeding, Neonatal Care, Neonatal Disease, Neonatal Drugs, Neonatal Health, Neonatal Infections, Neonatal Intensive Care, Neonatal Seizure, Neonatal Sepsis, Newborn Jaundice, Newborns Screening, Premature Infants, Sepsis in Neonatal, Vaccines and Immunity for Newborns