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AMR is said to be a microbe's ability to withstand the effects of medicine that could once therapize the microbe successfully. The term antibiotic resistance (AR or ABR) is an AMR exclusion because it refers only to the bacteria being antibiotic-resistant. Resistant microbes are more difficult to treat, requiring alternative medicines or higher antimicrobial doses. These can be more costly, higher risk of toxicity, or both. Numerous antimicrobial-resistant microbes are called Multidrug-Resistant (MDR). The drug resistance levels are extensively drug-resistant (XDR) and fully drug-resistant (TDR).