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Progress Towards The Development Of A Glycoconjugate Vaccine Against Helicobacter Pylori | 25209
ISSN: 2161-069X
Journal of Gastrointestinal & Digestive System
Open Access
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Helicobacter pylori infection is particularly common in developing countries as well as Indigenous populations of North
America and has been associated with chronic gastritis and increased risk of ulcers and gastric cancer in adults.
Author?s group has been interested in the development of a conjugate vaccine based on lipopolysaccharide (LPS), a major cell
surface component of H. pylori. It has been identified a common antigenic LPS core epitope, α-1,6-glucan, and have recently
demonstrated that synthetic glycoconjugates based on a truncated H. pylori LPS devoid of Lewis antigens and presenting an
α-1,6-glucan epitope in the outer core region induced broadly cross-reactive bactericidal antibodies in immunized animals
and conferred partial protection against H. pylori challenge in a mouse model. To investigate the candidacy of α-1,6-glucan as
an alternative vaccine strategy we prepared glycoconjugates based on dextrans produced by lactic acid bacteria Leuconostoc
mesenteroides B512F. The conjugates were immunogenic in both rabbits and mice and induced specific IgG responses against
α-1,6-glucan-expressing H. pylori LPS. Future studies will focus on further development of H. pylori vaccine formulations,
including the choice of carrier proteins and adjuvants.
Biography
Eleonora Altman is a Senior Research Officer at the National Research Council of Canada and has joined NRC in 1984 after receiving her PhD degree in
Carbohydrate Chemistry from the University of British Columbia. She has an extensive expertise in structural characterization of bacterial polysaccharides and
application of NMR spectroscopy and mass spectrometry to structural analysis. Over the past 15 years, she has been involved in studies related to the role of
lipopolysaccharide in the pathogenesis of Helicobacter pylori. She has published 95 papers in international journals within the area of structural analysis and
glycobiology.
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