Leandro Bueno B | OMICS International

Cardiovascular Therapy: Open Access
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Leandro Bueno B

Escola Paulista de Medicina

The “Calcium Paradox” due to Ca2+/cAMP Interaction and Antihypertensive Pharmacotherapy: New Avenues for Drug Development

In 2013, we showed that the paradoxical effects (sympathetic hyperactivity) induced by L-type voltage-activated Ca2+ channels (VACC) blockers, named by us “calcium paradox” phenomenon, were potentiated by drugs which increase cytosolic cAMP concentration ([cAMP]c-enhancers), for example rolipram, IBMX and forskolin, indicating that the ... Read More»

Leandro Bueno B and Caricati Neto A

Short Communication: Cardiovasc Ther 2017, 2: 117

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