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Raj Jatin Shah | OMICS International
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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Raj Jatin Shah

USA
Publications

Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome

Down syndrome is one of the most common genetic conditions occurring in one in 700 live births. The trisomy of chromosome 21 causes over-expression of APP which in turn is indicated in the increased production of Aβ associated with AD. This makes DS the most common presenile form of AD exceeding PS1 and PS2 FAD. Since a majority of DS individu... Read More»

Boris DeCourt, William Mobley, Eric Reiman, Raj Jatin Shah and Marwan N Sabbagh

Review Article: J Alzheimers Dis Parkinsonism 2013, S7-002

DOI: 10.4172/2161-0460.S7-002

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF Mobile Full Article

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