alexa ABHIJIT BASU | Bose Institute - Jadavpur University

Cardiovascular Therapy: Open Access
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Associate Professor
Bose Institute - Jadavpur University

I have earned my BSc and MSc degrees in Chemistry (Honors) and Biochemistry respectively from Calcutta University, India. I obtained my PhD from Bose Institute, India where I have studied the interaction of a mycobacterial plasmid DNA replication origin with replication protein. I served as a post doctoral fellow at Memorial Sloan Kettering Cancer Center, New York, USA in the laboratory of Prof. Jerard Hurwitz who is a member of National Academy of Science and is famous for his pioneer research on RNA polymerase and eukaryotic DNA replication. I moved to Cleveland State University in 2008 and currently working as a senior research associate.

Research Interest

My research is focused on post transcriptional regulation of pro-inflammatory gene expression. Our group has discovered a translational silencing mechanism in myeloid cell that can resolve hyper inflammation. A ribosomal protein is central to this mechanism which appears to control levels of several chemokines and chemokine receptors in response to interferon gamma treatment. We showed that disruption of this mechanism in macrophage results in greater diet induced atherosclerosis in apoE KO mice.


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