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Dr. Cara Westmark is an Associate Scientist at the Waisman Center for Developmental Disabilities at the University of Wisconsin-Madison. Her current research examines the role of genetic and environmental factors on the expression of amyloid precursor protein (APP) and beta-amyloid (A beta) in transgenic mouse models of neurological disorders. She has demonstrated that APP/ A beta levels are altered in Fragile X syndrome and that many FXS phenotypes can be rescued in a mouse model of the disorder by genetically reducing APP/ A beta. These data suggest that therapies studied for the treatment of Alzheimer’s disease (AD) may be beneficial in the treatment of FXS. She has also demonstrated a strong association between APP/ A beta over-expression and lower seizure threshold, which has important implications for the treatment of seizure-related disorders such as AD, FXS and Down syndrome. Her most recent work has demonstrated a strong association between dietary phytoestrogen consumption, elevated A beta and reduced seizure threshold.
Cara current research examines the role of genetic and environmental factors on the expression of amyloid precursor protein (APP) and beta-amyloid (A Beta) in transgenic mouse models of neurological disorders.
|Cara J. Westmark, Crystal M. Hervey, Elizabeth M. Berry-Kravisc and James S. Maltera|
|Rapid Communication: J Alzheimers Dis 2011, 1:101|
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