alexa Editor - Yuan Hu | Merck Research Laboratories, Merck & Co., Inc | 24601
ISSN: 2572-0406

Journal of Chemical Biology & Therapeutics
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Yuan Hu

Yuan Hu
Yuan Hu,  Merck Research Laboratories, Merck & Co., Inc., Kenilworth,  USA

Biography

Dr. Yuan Hu is a research scientist in Merck & Co., Inc at Kenilworth, New Jersey, USA. He received his Ph.D. in Computational Chemistry from University of Delaware mentored by Professor Sandeep Patel. Dr. Yuan Hu has a broad set skills of structure-based and ligand-based drug design including virtual screening, docking, molecular dynamics simulation, free energy calculations, QSAR. He has deep understandings of computational modeling techniques in hypothesis-driven drug discovery and practical experience in creation and application of informatics and modeling tools to advance drug discovery and development processes. He has expertise in free energy calculations, such as FEP/TI, MMGBSA/MMPBSA, LIE, alanine/residue scanning, expertise in building workflows to automate the challenging modeling work, expertise in working with small molecule, peptide and biologics drug design. He has been working on protein-ligand binding affinity prediction, peptide passive permeation prediction, HDX spectrum prediction, D3R blinded prediction challenge of ligand poses and ranking on pharmaceutical data sets. Additionally, he has a master degree in organic chemistry, and a solid publication record with hands on experience in organic synthesis and catalysis including transition metal catalyzed reactions.

Research Interest

Computational Chemistry; Molecular Dynamics; Structure-Based Drug Design; Ligand-Based Drug Design; Virtual Screening; Protein-Ligand Binding; Pose Prediction; Docking; Free Energy Calculation; Workflow Development; Cell-Penetrating Peptide; Biologics; Antibody; HDX; Membrane Permeation; Membrane Biophysics.

Publications

Mitochondrial DNA Sequencing of Middle Neolithic Human Remains of Ling-Ding Site II: Implication for the Social Structure and the Origin of Northeast Coast Taiwaneses

The Association between Helicobacter Pylori Infection and Metabolic Syndrome in a Taiwanese Adult Population

Jin-Yuan Huang, Jean A. Trejaut, Chien-Liang Lee, Tse-Yi Wang, Jun-Hun Loo, Zong-Sian Chen, Lan-Rong Chen, Ke-Hung Liu, Yi-Chang Liu, Cheng-Heng Hu and Marie Lin
Research Article: J Phylogenetics Evol Biol 2018, 6: 200
DOI: 10.4172/2329-9002.1000200

Circulating Tumor Cells (CTCs) as Biomarker for PD-1/PD-L1 Blockade Immunotherapy

Yu-Chen Chang, Chun-Yuan Huang, Lee-Ching Hwang and Chia-Chen Chang
Research Article: J Metabolic Synd 2017, 6: 234
DOI: 10.4172/2167-0943.1000233

Tissue Donation after Withdrawal of Life-Sustaining Treatment as an Advanced Care Plan is One of the Options in End-of-Life Care

Chunyan YUE and Zhiyuan HU
Short Communication: J Cancer Sci Ther/Vol.9.8 593(2017)
DOI: 10.4172/1948-5956.1000479

Potential Roles of Cancerous Immunoglobulins in the Immunology of Cancer Cells

Chih-Chuan Hsieh, Chiao-Zhu Li, Meng-Chi Li, Yun-Ju Yang, Kun-Ting Hong, Chi-Tun Tang, Tzu-Tsao Chung, Da-Tong Ju, Chun-Chang Yeh, Yuan- Hao Chen and Dueng-Yuan Hueng
Research Article: J Palliat Care Med
DOI: 10.4172/2165-7386.1000282

Two Distinct Humanized Monoclonal Antibodies for Immunotherapy of Ovarian Cancer

Gregory Lee, Cheng-Yuan Huang, Yiting Tang and Hao Zhang
Research Article: J Clin Cell Immunol 2014, 5: 200
DOI: 10.4172/2155-9899.1000200

Humulus Scandens Chemical Constituents Determination and Pharmacological Action Research

Gregory Lee, Cheng-yuan Huang and Bixia Ge
Review Article: J Cancer Sci Ther/Vol.6.3 110-116 (2014)
DOI: 10.4172/1948-5956.1000258
Zaixing Chen, Shu Meng, Jiao Yang, Hongguang Nie, Hong Jiang, Huiyuan Hu and Fanhao Meng
Research Article: Med Chem (Los Angeles) 2012, 2:029
DOI: 10.4172/2161-0444.1000109
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