Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar


Chill Burn after Cryotherapy in a Thrombocytopenic Recipient: The Adverse Effect of Thrombocytopenia on Dermal Wounding | OMICS International
ISSN: 2332-0702
Journal of Oral Hygiene & Health
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.

Chill Burn after Cryotherapy in a Thrombocytopenic Recipient: The Adverse Effect of Thrombocytopenia on Dermal Wounding

Imataki O1*, Ohbayashi Y2, Ohue Y3, Oku M1, Matsuka H3 and Uemura M1

1Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan

2Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan

3Nursing Division, Kagawa University Hospital, Kagawa, Japan

*Corresponding Author:
Dr. Osamu Imataki
Division of Hematology
Department of Internal Medicine
Faculty of Medicine, Kagawa University
1750-1 Ikenobe, Miki-cho, Kita-gun
Kagawa 761-0793, Japan
Tel: +81-878-91-2145
Fax: +81- 878-91-2147

Received Date: December 29, 2015; Accepted Date: January 30, 2016; Published Date: February 07, 2016

Citation: Imataki O, Ohbayashi Y, Ohue Y, Oku M, Matsuka H, et al. (2016) Chill Burn after Cryotherapy in a Thrombocytopenic Recipient: The Adverse Effect of Thrombocytopenia on Dermal Wounding. J Oral Hyg Health 4:196. doi:10.4172/2332-0702.1000196

Copyright: © 2016 Imataki O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Oral Hygiene & Health


Cryotherapy; Stem cell transplantation; Thrombocytopenia; Oral care; Supportive care; Chill burn; Oncology


Cryotherapy; Stem cell transplantation; Thrombocytopenia; Oral care; Supportive care; Chill burn; Oncology

Case Report

A 64-year-old Japanese female diagnosed with aplastic anemia underwent stem cell transplantation (SCT) from an unrelated donor with a reduced-intensity conditioning regimen. Oral cryotherapy is the evidence-based standard for cancer patients [1], and transplant recipients are routinely treated with preparations containing high-dose melphalan, in collaboration with an oral care team. She therefore received preparation chemotherapy, consisting of fuludarabine (25 mg/m2/day for five consecutive days, from day −6 to day −2; total 125 mg/m2) and melpharan (90 mg/m2/day for two consecutive days, day −3 and day −2; total 180 mg/m2) prior to stem cell infusion (day 0). Oral cryotherapy was performed on both days of melphalan administration, she received oral cryotherapy, consisting of orally administered ice chips and application of a refrigerant pack cooled to −20°C. Cooling was started 30 min before melphalan administration, continued through the 15 min of melphalan administration, and stopped 30 min after melphalan administration (total 75 min). Although this protocol eliminated oral mucositis, the patient developed a frostbite-like skin eruption 3 days before transplantation (Figure 1), lasting from day −3 to day 3. This eruption was temporary and cured itself, without progressing to erosion or ulceration.


Figure 1: Frostbite-like skin rash (arrows) observed in the patient on the day of transplantation (day 0).

Cryotherapy has been shown to be effective supportive care for patients receiving chemotherapy, which frequently induces oral mucositis [2,3]. Oral cryotherapy has been found to alleviate mucositis in patients treated with high-dose melphalan, together with both non-myeloablative [2] and myeloablative [3] treatment regimens. Although some adverse effects have been observed in clinical practice, these have never been reported in clinical studies due to their relatively low severity.

Several reports have described the effects of thrombocytopenia on wound healing [4,5]. Wound healing usually starts as platelet activation and hemostasis, but the role of platelets is not limited to coagulation. Rather, platelets are involved in other aspects of tissue protection. For example, thrombocyte count has been associated with increased levels of complement components and coagulation factors [6], which are required for tissue remodeling. In addition, platelet-derived growth factor (PDGF) and fibroblast growth factors(FGF) secreted by thrombocytes have been shown to be attenuation factors involved in healing connective tissues [4]. Stromal cellderived factor-1α (SDF-1α) is another important mediator of wound healing, recruiting CD34+ stem cells to local sites [5]. Neutrophils are also involved in the wound healing process [7]. PDGF and FGF promote angiogenesis and enhance the concentrations of additional cytokines, including tumor necrosis factor-α (TNF-α), in the microenvironment, suppressing inflammation and apoptosis and supporting healing reactions [5]. Recent clinical research has shown that cytokines in platelet-rich plasma (PRP) can promote the repopulation of fibroblasts and other soft tissue cells [8].

This case study showed that oral cryotherapy can have adverse effects, especially when combined with a patient’s hematological condition, such as thrombocytopenia and neutropenia. These adverse effects, however, are subtle and of low grade when assessed by clinical toxicity criteria (CTC-AE). These findings indicate that the degree of cooling of refrigerant packs be modified in cytopenic patients to avoid skin damage.

Competing Interests

The authors declare that they have no competing interests.

Conflict of Interest

The authors declare that they have no competing interests.

Ethics, Consent and Permissions

Informed consent to participate in the study was obtained from the participant.

Consent to publish

Informed consent to publish was obtained from the participant.


Post your comment

Share This Article

Article Usage

  • Total views: 11583
  • [From(publication date):
    March-2016 - Apr 18, 2024]
  • Breakdown by view type
  • HTML page views : 10811
  • PDF downloads : 772