Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar


Periodontal Disease and Phytotherapy | OMICS International
ISSN: 2332-0702
Journal of Oral Hygiene & Health
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business

Periodontal Disease and Phytotherapy

Petrovic MS1, Kesic LG1*, Kitic DV2, Milašin JM3, Obradovic RR1, Bojovic MD1, Simonovic AA4

1Department of Oral Medicine and Periodontology, Dental Clinic, Faculty of Medicine, University of Niš, Serbia

2Department of Pharmacy, Faculty of Medicine, University of Niš, Serbia

3Department of Molecular Biology and Genetics, Faculty of Dental Medicine, University of Belgrade, Serbia

4Faculty of Medicine, University of Niš, Serbia

*Corresponding Author:
Ljiljana Kesic
Dental clinic, Medical faculty University of Niš
Department for Oral Medicine and Periodontology
Bulevar Zorana Ðindica 81, 18 000 Niš, Serbia
Tel: +381-64-26-700-99

Received Date: January 26, 2015; Accepted Date: March 03 2015; Published Date: March 10, 2015

Citation: Petrovic MS, Kesic LG, Kitic DV, Milašin JM, Obradovic RR, Bojovic MD, Simonovic AA (2015) Periodontal Disease and Phytotherapy.J Org Hyg Health 3:172. doi:10.4172/2332-0702.1000172

Copyright: ©2015 Petrovic et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Oral Hygiene & Health


Phytotherapy is used as an additional therapeutic method of treatment for gingivitis and periodontal disease. Besides its therapeutic effects, it has a role in improving general immunity. Herbs and their extracts have antimicrobial, antioxidative and antiinflammatory effects. Aim of this review article is to give a basic overview of usage of herbal species in treatment of periodontal disease. Besides causal treatment for periodontal disease, which represents “gold standard'' of periodontal therapy, the proper combination of herbal species and their extracts can improve the usual therapeutic procedure in patients with gingivitis and periodontal disease.


Phytotherapy; Periodontal disease; Gingivitis


The periodontal disease is a major public health problem, which affects up to 90% of the worldwide population [1]. Gingivitis always precedes periodontal disease. The main characteristic of periodontal disease is destruction of supporting tissue of the tooth. The main etiological factor is microbial oral biofilm. Periodontal pathogens are: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Treponema denticola etc. Aggregatibacter actinomycetemcomitans is commonly associated with this disease, especially in young adults [2,3]. Some new studies [4,5] demonstrate that Herpes viruses can be involved in pathogenesis of periodontal disease. Periodontal inflammation is followed by release of bacterial leucotoxins, collagenases, fibrinolysins, and other proteases [6]. Increased leukocyte infiltration and changes in vascular permeability have always been present in periodontal tissues inflammation [7]. Antibiotics (tetracyclines and metronidazole), antiseptics (chlorhexidine), phenols, oils, and herbal compounds have been in use since 1980 [8].

Since the tooth cleaning is essential for maintaining of oral hygiene, indigenous people, worldwide, have used natural toothbrushes made �??�??of herbs. These natural toothbrushes, made �??�??of twigs, actually work quite well. They contain medical ingredients produced by the herb itself. In Asia, people often use twigs of the neem tree (Azadirachta indica) [9,10].

Haffajee et al. [11] have been examining herbal product, the Natural Dentist, Medford, Mass®, that contains several anti-inflammatory agents: aloe vera, calendula, as well as antimicrobial agents such as Golden Seal, grapefruit seeds and they concluded that herbal mouth rinse had beneficial effects such as reducing gingival inflammation and inhibiting of aerobic and anaerobic bacterial growth.

It has been experimentally confirmed that extraction of certain chemicals from herbs destroys minerals, volatile oils, bioflavonoids and other substances in high percentage [12,13]. Herbs and their extracts are used to stimulate superficial circulation, increase elimination of harmful substances and reduce inflammation and irritation. Herbal products may be used as pills, syrups and infusions or externally as creams, ointments and liniments. A topical application of clove oil, for instance, decreases the toothache [8]. Using new clinical trials about herbal products published every year [13], makes collecting evidence about herbs’ medical properties a dynamic and quick process.

Herbal species with medical properties have been used for centuries to prevent and treat different diseases [8,9,12,13]. The biggest problem is the lack of information about effects of herbal species on periodontal tissues and mechanism of action. Herbal products may vary in their effectiveness, therefore it is necessary to select herbal species carefully. Herbs and their extracts can be used as adjuvant in periodontal disease treatment [8].

Sage (Salvia officinalis)

Sage belongs to Laminaceae family. Sage grows in the fields and along roadsides. It can be used as mouth rinse and it has been recommenended for treatment of sore throat, stomatitis, gingivitis and periodontal disease (14). Sage essential oils have antibiotic, antifungal and antiviral properties and it has been used to reduce inflammatory process in stomatitis and pharyngitis [14]. For therapy: 3g of sage chopped leaf could be added to 150 ml of boiling water for 10 minutes [15]. Then, it can be used as a mouth rinse several times a day. Another prescription for mouth rinse is: two tablespoon of sage chopped leaf immersed in half a liter of water, covered and brought to a boil and then left covered for 15 minutes-this can be used for gargling several times a day for 5 to 10 minutes [15]. Pistorius et al. [16] have reported a significant reduction in gingival indices with daily use of mouth rinse and concluded that it could be used every day as an adjunctive therapy to reduce gingival inflammation and it contains following herbal species: Salvia officinalis, Mentha piperita (menthol), Matricaria chamomilla, Commiphora myrrha, Carum carvi (Umbelliferae), Eugenia caryophyllus (Myrtaceae) and Ehinacea purpurea. Salvia officinalis has aromatic, spasmolytic, antiseptic, astringent properties and when it is taken as a mouthwash, Salvia deals effectively with throat infections, gingivitis and mouth ulcers [17].

Drinking sage tea is not recommended during pregnancy and lactation, but mouth rinse and gargling is allowed [8].

Aloe vera (Aloe vera)

Aloe vera belongs to Asphodelaceae family. It contains vitamins, enzymes, minerals, sugars, fatty acids, amino and salicylic acids [18]. Aloe vera (in the form of a gel) improves wound healing and it can be used for burns, insect-bites and many other skin and mucosal lesions. Because of numerous healing properties of aloe vera, it has been used as dietary supplement and powerful antioxidant, as wound healing accelerator, after periodontal surgery, for traumatized gingival lesions by toothbrush, toothpick or solid food. Aloe vera (gel formula) is a non-toxic bactericide and it has antiviral, antifungal, anti-inflammatory, analgesic properties and immune-stimulating properties [18-20]. The anti-inflammatory activity of Aloe vera inhibits the cyclooxygenase pathway and reduces prostaglandin E2 production [21].

Scherer et al. [22] confirmed that a mouth rinse, which contains Aloe vera reduces gingival inflammation and bleeding. A short-term study by Bhat et al. [23] demonstrated that aloe vera gel showed significant decrease in pocket depth and relative decrease in gingival and plaque indices, when applied subgingivally.

Aloe vera gel applications directly to the site of periodontal surgery or to gingiva when it has been traumatized with a tooth brush dentifrice abrasion, sharp foods, dental floss and toothpick injuries have shown improved healing properties [24]. Aloe vera gel at optimum concentrations in toothpastes or mouthwashes could be useful for prevention of periodontal diseases and dental caries [25].

Chamomile (Matricaria recutita or Matricaria chamomilla)

Chamomile (Matricaria recutita) belongs to Asteraceae family and it is one of the most popular herbs. It is used as ingredient of mouth rinse and in prevention and treatment of gingivitis and periodontal disease. It can also be used in the form of capsules, tablets, or tinctures [8].

McKay and Blumberg [26] demonstrated anti-inflammatory activity in an animal model study. Lucena et al. [27], found a reduction in the gingiva bleeding index, confirming the findings of this study, in which the mouthwash with Matricaria recutita extract also reduced the bleeding index, both in gingivitis and in chronic periodontitis, showing statistically significant results (p<0.05) in the different assessment periods (0,7 and15 days). Batista et al. [28] used chamomile and pomegranate extracts mouthwashes, which were effective in reducing gingival bleeding in periodontal disease, suggesting that both extracts have anti-inflammatory and antimicrobial actions similar to those of the chlorhexidine 0.12%, and thus can also be used as additional therapeutic agents to reestablish and maintain periodontal health.

There have been reports of allergic reactions to chamomile (Matricaria recutita) [29]. These reactions were followed by bronchial constriction with systemic administration and skin reactions after topical application

Peppermint (Mentha piperita)

Peppermint (Mint) belongs to Laminaceae family, and it reduces inflammation. In addition, it has been used to reduce the toothache, with cotton balls soaked in peppermint oil and put in the tooth cavity [8]. Peppermint oil, when used locally, has an analgesic effect [15]. Peppermint leaf tablets and capsules, 3–6 g per day, diluted, could be used as a mouth rinse to reduce gingival inflammation after periodontal treatment [8]. Essential oil and peppermint leaves are used for making mouth rinses and gels that affect the periodontal bacteria [31].

The most important phenolic compounds in Mentha species are flavonoids and they are found to poses a wide range of pharmacological activity: antioxidant, antiulcer, cytoprotective, chemo preventive and anti-inflammatory [32].

Peppermint tea is generally considered safe for regular consumption. Peppermint oil can cause sensation in gastrointestinal tract for some people [33].

Tea tree (Melaleuca alternifolia)

Tea tree or Melaleuca alternifolia belongs to Myrtacea family. It can be applied directly on the inflamed gums, for instant relief [8]. Mouth rinse reduces inflammation and it has been used in endodontic and necrotic pulp treatment [11]. Melaleuca alternifolia has shown good effectiveness in control of microbial biofilm, with a significant reduction of gingival bleeding index [34]. Santamaria et al. [35] evaluated the antimicrobial effects of tea tree essential oil gel in controlling of oral microbial biofilm formation and they established its effectiveness against bacteria.

Tea tree oil has demonstrated the ability to suppress the in vitro production of inflammatory cytokines, suggesting its potential as a therapeutic agent for inflammatory diseases, such as periodontal disease, via modulation of the host response [36].

Ehinacea (Purple coneflower)

Ehinacea, a herb that belongs to Asteraceae family, boosts the immune system [37]. Its constituents act together to increase production and activity of white blood cells (lymphocytes and macrophages). Mouth rinse with ehinacea, sage, mint oil and chamomile is used in gingivitis and periodontal disease treatment [37]. Kumar et al. [31] reported anti-inflammatory and antibacterial effects of ehinacea. Several studies [38-40] testified to its benefit for natural treatment of cold and flu symptoms.

Rosemary (Rosmarinus officinalis)

Rosemary belongs to Lamiaceae family and its volatile oil has antibacterial and antifungal properties. It is effective against chronic disseminated candidiasis [41].The concentrated volatile oil should not be given orally [42]. Other studies [43,44] about the properties of rosemary’s essential oil demonstrated its antimicrobial and antioxidative activity. Santoyo et al. [45] examined rosemary’s antimicrobial activity and they concluded that the following five components of essential oil are responsible: borneol, 1,8-cineole, camphor, verbenone and α-Pinene. Borneol has given better results in antimicrobial activity, followed by camphor and verbenone [45]. Lee et al. [46] found that rosmarinic acid caused significant induction of alcalin-fosfatase activity and induced mineralization in osteoblasts, so it could be used to prevent bone metabolic diseases.

Red clover (Triofilum pretenase)

Red clover belongs to Fabaceae family. Red clover mouthwash has been used in treatment of gingivitis and periodontal disease. After preparing the red clover tea, leaves and flowers can be used for preparing the gel with antibiotic properties. Ramos et al. [47] have shown the anti-inflammatory activity of red clover dry extract in their in vitro and in vivo studies.

Wintergreen (Gaultheria procumbens)

Wintergreen belongs to Ericaceae family. Wintergreen mouth rinse is an excellent adstringent and antiseptic. A cotton ball soaked in wintergreen oil is used for temporary relief and as remedy for sore throat and gum inflammation [9]. Nikoli�? et al. [48] have shown antimicrobial activity of Wintergreen essential oil against wide range of Gram-positive and Gram-negative bacteria and fungi, as well as its antioxidant potential.

Barberry (Berberis vulgaris)

Barberry belongs to Berberidaceae family. Berberine, alkaloid from Berberis vulgaris, has been added to toothpastes and mouth rinses due to its antimicrobial activities [49]. Barberry gel has been used as efficient adjuvant for oral biofilm control and for reduction of gingival inflammation in children [50]. Berberry juice contains high level of vitamin C and increases host-immune response and stimulates iron absorption [51]. Enzo i Palombo [52] have demonstrated that alkaloids such as berberine were more effective against bacteria such as Aggregatibacter actinomycetemcomitans and Porfyromonas gingivalis than against lactobacilli and streptococci. Berberine also inhibited collagenase activity of Aggregatibacter actinomycetemcomitans and Porfyromonas gingivalis.

Makarem et al. [50] examined berberine gel and concluded that it reduces oral biofilm by 56% and gingival index by 33% (GI). Studies [53,54] have indicated that berberine has multiple pharmacological activities including anti-inflammatory, anti-cyclooxygenase, and anti-inducible nitric oxide synthases effects. It is suggested that berberine may decrease the periodontal tissue degradation through the regulation of matrix metalloproteinase during the progression of periodontal disease [55].


Phytotherapy, as additional therapeutic method, has been expanding rapidly, conquering the whole world. Herbs and their extracts have been used as adjuvants in periodontal treatment because they reduce inflammation and act as antioxidants and antibiotics. The usage of herbal products in periodontal treatment has a great potential, but it is a challenge to determine the proper combination of herbal species and their extracts.


Post your comment

Share This Article

Article Usage

  • Total views: 18916
  • [From(publication date):
    March-2015 - Jul 14, 2024]
  • Breakdown by view type
  • HTML page views : 13998
  • PDF downloads : 4918