alexa Precision Medicine
ISSN: 1522-4821
International Journal of Emergency Mental Health and Human Resilience
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Precision Medicine

Florence Thibaut1, Michel Bourin2*

1Professor of Psychiatry, University Hospital Cochin (Site Tarnier), Paris-Descartes University, Centre Psychiatry and Neurosciences, Paris, France

2Professor of Pharmacology, University of Nantes, France

*Corresponding Author:
Michel Bourin
E-mail: michel.bourin@univ-nantes.fr

Visit for more related articles at International Journal of Emergency Mental Health and Human Resilience

Abstract

Precision medicine will become the newest hot topic in the research world. The director of the prestigious NIMH, Tom Insel, explained two weeks ago in his blog: ?President Obama spoke about precision medicine in his State of the Union speech?on January 20, his budget released today requests $215M for precision medicine, and NIH just announced plans for a study of a million or more volunteers to explore precision medicine. What precisely is it? The White House website? has a useful definition: getting the right treatment at the right time to the right person?.

Precision medicine will become the newest hot topic in the research world. The director of the prestigious NIMH, Tom Insel, explained two weeks ago in his blog: “President Obama spoke about precision medicine in his State of the Union speech on January 20, his budget released today requests $215M for precision medicine, and NIH just announced plans for a study of a million or more volunteers to explore precision medicine. What precisely is it? The White House website has a useful definition: getting the right treatment at the right time to the right person”.

What does it mean for psychiatry?

In the real life, significant inter-individual variability exists in psychotropic drugs response, therapeutic dosage, and adverse effects profile. Less than two thirds of patients respond to antidepressants, or to specific antipsychotics, but psychiatrists have learned with their personal skills to adapt the medical thesaurus to their patient population. However, prolonged times to response or remission represent a period of suffering associated with an increased risk for morbidity and mortality. Improving psychiatric treatments prescription, using a more biologically informed selection of psychopharmacologic agents through genotyping, has become a reality in clinical psychiatry . Routine genotyping has now become available to search for gene variations that code for proteins involved in neurotransmission and for enzymes involved in the metabolism of many pharmacological agents . Clinical validation and reliability of genotyping, access to testing, uniformity and clarity in test interpretation, and clinician and patient education are critical to this process of innovation diffusion.

How can precise medicine be applied to psychiatry?

Psychiatric classifications have remarkably evolved with time (DSMs, ICDs) so diagnosis is not the same constant as is the case in cardiovascular diseases, patients can fluctuate at different times between anxiety, depression and even bipolarity, and treatments can be adapted accordingly.

 

Yet, the classical aspects of precision medicine relating genotype to diagnosis and treatment, is particularly difficult in psychiatry . De Leon (2009) argued that there is no potential for pharmacogenetic testing to ascertain the best drug for each patient, and that pharmacogenetic tests will be restricted only to excluding some drugs from unusual patients and for using genes involved in drug metabolism for personalized dosing of drugs with narrow therapeutic windows (e.g. lithium where plasma level measurement is an essential part of treatment or clozapine where blood monitoring is essential). The field of personalized medicine was also criticized by Holmes et al. (2009) in a full review of 1,668 primary research articles. He concluded that the field was polluted by reviews and commentaries in a ratio of 25: 1 compared with primary articles.

First of all, it is necessary, because of the low penetrance of single genetic polymorphisms in psychiatric disorders and the certain importance of epigenetic changes, to use many different techniques in combination (electrophysiology, imaging, in association with pharmacogenetics), in order to better understand cerebral networks, before moving towards personalized medicine . The improvement of our knowledge of the causes of certain psychiatric disorders will lead to the identification of reliable biological markers (for review see Thibaut et al., 2015), which lack to date, and therefore, to personalized medicine.

References

http://www.nimh.nih.gov/about/director/2015/ precision-medicine-for-mental-disorders.shtml

De Leon, J. (2009). The future (or lack of future) of personalized prescription in psychiatry. Pharmacol Res, 59(2), 81-89.

Holmes, M.V., Shah, T., Vickery, C., Smeeth, L., Hingorani, A.D. & Casas, J.P. (2009). Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. PLoS One, 4(12), e7960.

Thibaut, F., Boutros, N.J., Jarema, M., Oranje, B., Hasan, A., Daskalakis, Z.J. et al., & members of the WFSBP-Task Force on Biological Markers. (2015). WFSBP-Consensus criteria for biomarkers of schizophrenia. The World Journal of Biological Psychiatry, in press.

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 11695
  • [From(publication date):
    March-2015 - Aug 23, 2017]
  • Breakdown by view type
  • HTML page views : 7859
  • PDF downloads :3836
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords