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The Value of Ultrasonographic Measurement of Flow Mediated Dilatation | OMICS International
ISSN:2167-7964
OMICS Journal of Radiology
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The Value of Ultrasonographic Measurement of Flow Mediated Dilatation

Christopher LAI*
Assistant Professor, Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong
Corresponding Author : Christopher LAI
Assistant Professor
Department of Health Technology and Informatics
Hong Kong Polytechnic University, Hong Kong
Tel: +852 2899 0822
E-mail: [email protected]
Received October 13, 2014; Accepted October 14, 2014; Published October 17, 2014
Citation: Christopher LAI (2014) The Value of Ultrasonographic Measurement of Flow Mediated Dilatation. OMICS J Radiol 3:e129. doi: 10.4172/2167-7964.1000e129
Copyright: © 2014 Christopher LAI. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The perturbation of brachial blood flow by ultrasonographic measurement of hyperemia using Flow Mediated Dilatation (FMD) method was a valid method in the measurement of vascular dysregulation in the conduit artery. This method has been intensively used to measure the cardiovascular risk for many decades [1], and the Flammer [2], one of the first research groups using the FMD method, has provided plenty of evidence of systemic endothelial dysfunction in many disease conditions including hypertension [3] and diabetes [4].
Endothelial dysfunction occurs when healthy endothelium loses its ability to maintain vascular homeostasis in response to risk factors resulting in vasoconstriction, thrombosis and vascular smooth muscle cell proliferation. Nitric Oxide (NO) is the main vasodilator secreted by the endothelium. It is synthesized from L-arginine by endothelial Nitric Oxide Synthase (eNOS) in the presence of cofactors including tetrahydrobiopterin, resulting in the production of NO and L-Citrulline. NO then diffuses into the vascular smooth muscle cells, activating guanylatecyclase, leading to an increased production of cyclic guanosine monophosphate and a decrease of intracellular calcium. Numerous studies have consistently reported Statins can improve endothelial function by reducing the expression of inflammatory cytokines and growth factors, inhibits angiotensin II induced oxidative stress and enhances activity of endothelial NOS, thereby increasing NO bioavailability. However, the evidence reported from the use of antioxidants is conflicting. Vitamin C has been proven to cause an impact on endothelial function in smokers. However, a large-scale randomized study demonstrated that vitamin E did not have a beneficial effect on cardiovascular events in high-risk patients [4]. Another cohort study using a combination of antioxidants (betacarotene, vitamin C, vitamin E) also demonstrate no improvement in endothelial function [3].
To sum up, the validity and accuracy of the detection of endothelial dysfunction and new cardiovascular risk markers are extremely important to prevent the early onset of cardiovascular disease, and ease the heavy finical burden to the patients, hospital and society.
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