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Hindi Research Article
A Comparative Pharmacokinetic study of Aspirin Suppositories and Aspirin Nanoparticles Loaded Suppositories
| Ravi Sankar V1*, Dachinamoorthi D2 and Chandra Shekar KB3 | |
| 1Department of Pharmaceutics, C.E.S College of Pharmacy, Kurnool, India | |
| 2Department of Pharmaceutics, Q.I.S College of Pharmacy, Ongole, India | |
| 3Department of Chemistry, J.N.T.A University, Anantapur, India | |
| Corresponding Author : | V. Ravi sankar Department of Pharmaceutics C.E.S College of Pharmacy Kurnool-51812, Andhra Pradesh, India Tel: +919494422695 E-mail: ravisankarpharma@gmail.com |
| Received November 24, 2012; Accepted November 28, 2012; Published December 04, 2012 | |
| Citation: Ravi Sankar V, Dachinamoorthi D, Chandra Shekar KB (2012) A Comparative Pharmacokinetic study of Aspirin Suppositories and Aspirin Nanoparticles Loaded Suppositories. Clinic Pharmacol Biopharm. 1:105. doi:10.4172/2167-065X.1000105 | |
| Copyright: © 2012 Ravi Sankar V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
The main objective of the present work was to study the pharmacokinetic parameters and safety of the optimized aspirin suppositories and aspirin nanoparticles loaded suppositories and comparison both. ASA-nanoparticle prepared based on ionicgelation mechanism and optimized Fa9 formulation was isolated. ASA-suppositories prepared for the selection of best base composition and FS2, FS4, FS9, FS11 were selected for incorporation. Selected Fa9 formulation was incorporated into the selected based compositions based on fusion method and evaluated for various evaluation tests. The optimized formulation shows the drug release non-fickian type. Pharmacokinetic models were designed in rabbit model. Method developed in high performance liquid chromatography in rabbit plasma linearity was observed with r2=0.999 in sodium chlorite buffer pH 2.5, acetonitrile, and isopropyl alcohol flow rate of 2ml/min, retention time of 5.310 minutes was observed. Same validate method was used for the determination of various pharmacokinetic parameters Area under curve (AUC0-t), Area under zero infinity (AUC0-infinite), Cmax, Tmax, half life, elimination rate constant, Mean residence time. The histological examination was performed for four weeks at the end of each week animal was scarified and rectal tissue was isolated for histological examination. The comparative kinetics indicates the increase in Tmax, T1/2, AUC0-t and AUMC0-infinite, MRT in the ASA-nanoparticles loaded suppositories when compared with ASAsuppositories. Morphological examination revealed the histological changes such as ulceration and necrosis due to continuous use of ASA-suppositories. ASA-nanoparticles loaded suppositories proved to safe and effective with no observed histological changes.
