alexa Analysis of Mutagenic Potential of Therapeutic Vaccine Based on BPV-1 E6 Recombinant Protein Combined with Different Adjuvants | OMICS International| Abstract

Journal of Veterinary Medicine and Health
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  • Research Article   
  • J Vet Med Health,

Analysis of Mutagenic Potential of Therapeutic Vaccine Based on BPV-1 E6 Recombinant Protein Combined with Different Adjuvants

Rodrigo Pinheiro Araldi1,2, Diego Grando Módolo1, Jacqueline Mazzuchelli De Souza1,2, Rodrigo Franco De Carvalho1, Lucinéia Dos Santos3, Isabel Cristina Cherici Camargo3, Edislane Barreiros De Souza3 and Rita De Cassia Stocco1*
1Genetics Laboratory, Butantan Institute, , São Paulo-SP, Brazil
2Biotechnology Interunit Post-Graduation Program, Biomedical Science Institute, University of São Paulo (USP), , São Paulo-SP, Brazil
3Genetics Laboratory, Faculty of Sciences and Languages, São Paulo State University (UNESP), , Assis-SP, Brazil
*Corresponding Author : Rita De Cassia Stocco, Genetics Laboratory, Butantan Institute, 1500, Vital Brazil Avenue, Butnatã, São Paulo-SP, 055900-000, Brazil, Tel: +55 11 2627-9701, Fax: +55 11 2627-9701, Email: [email protected]

Received Date: Dec 18, 2017 / Accepted Date: Dec 25, 2017 / Published Date: Dec 30, 2017

Abstract

Bovine papillomavirus is a worldwide distributed virus that affects at least 60% of Brazilian cattle herd, causing significant economic loses. Considering the great number of BPV-infected bovines, therapeutic vaccines, such those based on E6 protein, are mandatory to control the BPV-related diseases. However, the choice of the adjuvant remains challenging the vaccinology field, since adjuvants are associated with local and systemic reactions. Thus, this study analyzed the cytotoxic and mutagenic potential of BPV-1 E6 protein-based vaccine formulations using different adjuvants: aluminum hydroxide, complete and incomplete Freund’s adjuvants and two anti-oxidant saponin-rich extracts obtained from Agave sisalana-alcoholic and acid hydrolysis extract. Results of these analyzes suggest that acid hydrolysis extract from A. sisalana is an alternative and useful candidate for therapeutic vaccines, being able to reduce the mutagenic potential of antigen.

Keywords: Papillomavirus; Vaccine; E6 protein; Adjuvants; Saponin

Citation: Araldi RP, Módolo DG, de Souza JM, de Carvalho RF, dos Santos L, et al. (2017) Analysis of Mutagenic Potential of Therapeutic Vaccine Based on BPV-1 E6 Recombinant Protein Combined with Different Adjuvants. J Vet Med Health 1: 102.

Copyright: ©2017 Araldi RP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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