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Hindi Research Article
Anticholinesterase and Antioxidant Potentials of a Medicinal Plant Abroma augusta: Implications for the Alternative Treatment Therapy of Cognitive Deficits in Alzheimers disease
| Mst. Marium Begum1, Kushal Biswas2, Arjyabrata Sarker3, Tamanna Binte Huq4, Abeer Sarwar4, Md. Belal Hossain5, Hasan Tarek5, Md. Noor-A-Alam5and Asma Rahman6* | |
| 1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh | |
| 2Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh | |
| 3Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh | |
| 4Department of Pharmaceutical Sciences, North South University, Dhaka-1229, Bangladesh | |
| 5Department of Pharmacy, Dhaka International University, Dhaka-1213, Bangladesh | |
| 6Centre for Advanced Research in Sciences (CARS), University of Dhaka, Dhaka-1000, Bangladesh | |
| Corresponding Author : | Asma Rahman Centre for Advanced Research in Sciences (CARS) University of Dhaka, Dhaka-1000, Bangladesh Tel: +8801718617915 E-mail: asmadupharma@gmail.com |
| Received: August 07, 2015; Accepted: October 23, 2015; Published: October 28, 2015 | |
| Citation: Begum MM, Biswas K, Sarker A, Huq TB, Sarwar A, et al. (2015) Anticholinesterase and Antioxidant Potentials of a Medicinal Plant Abroma augusta: Implications for the Alternative Treatment Therapy of Cognitive Deficits in Alzheimer’s disease. Clin Pharmacol Biopharm 4:148. doi:10.4172/2167- 065X.1000148 | |
| Copyright: © 2015 Begum MM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Oxidative stress and low level of neurotransmitter (especially acetylcholine) are main characteristics of Alzheimer’s disease (AD), a progressive neurodegenerative disease. Prolonging the function of acetylcholine by inhibiting acetylcholinesterase or butyrylcholinesterase enzyme and reducing oxidative stress with antioxidants are most effective treatment therapy of AD. Abroma augusta is a well-known medicine plant with a variety of medicinal uses. In this study we examine cholinesterase inhibitory activity as well as antioxidant activity of dried fruit extract including crude methyl extract and its sub fractions (Chloroform fraction, Petroleum ether fraction, Ethyl acetate fraction and aqueous fraction) of A. augusta. Both cholinergic inhibitory activity and antioxidant activity of various fractions suggested that, ethyl acetate fraction are most prominent among all fractions and can be used in symptomatic treatment of AD.
